Special Issue "Halogenated Metabolites"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 April 2019).

Special Issue Editors

Guest Editor
Prof. Soizic Prado Website E-Mail
Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Sorbonne Université, Muséum national d’Histoire naturelle, CNRS, CP 54, 57 rue Cuvier, 75005 Paris, France
Interests: chemistry of natural and microbial products; fungal and bacterial endophytes; secondary metabolites, marine natural products; genome mining; structural characterization; metabolomics; molecular networking
Guest Editor
Dr. Catherine Roullier Website E-Mail
MMS (Mer Molécules Santé) – EA2160, IUML - Institut Universitaire Mer et Littoral - FR 3473 CNRS, University of Nantes – Pharmacy Faculty 9 rue Bias, BP 61112, 44035 Nantes-cedex 1, France
Interests: natural products chemistry; metabolomics; bioactivity; marine fungi; halogenated secondary metabolites; mass spectrometry; bioinformatics

Special Issue Information

Dear Colleagues,

Halogens are abundant components of Earth’s biosphere and a huge diversity of organohalides ranging from single-carbon methylhalides to structurally far more complex compounds such as palau’amine are produced by living organisms.

The incorporation of halogens into organic molecules usually involves halogenating enzymes which are widely distributed among prokaryotic and eukaryotic organisms such as macroalgae, bacteria or fungi. Accordingly, a huge diversity of species is able to produce organohalides in both terrestrial and marine environments.

Chlorination is predominant, followed by bromination, while iodination and fluorination are rarer in Nature. In addition, while chlorinated compounds are quite ubiquitous in terrestrial environments, brominated compounds are mostly isolated from marine species. In such marine environment, these halogenated compounds are responsible for important biological functions ranging from chemical defense to signaling molecules. As a result, they also display potential application in human therapeutics.

The biogenesis of these compounds has intrigued scientists for decades and more recently, conserved DNA sequence motifs of various halogenases have been successfully exploited for the identification of new halogenated metabolites, as well as for cloning gene clusters that encodes the halogenated metabolites production.

Accordingly, in this Special Issue of Marine Drugs, we would like to cover different recent aspects related to naturally occurring halogenated compounds such as their detection in marine environments, their structural characterization, their biosynthesis and bioengineering, their ecological roles as well as their bioactivity. Consequently, we cordially welcome colleagues to contribute to this Special Issue with reviews, original papers, or short communications.

Prof. Soizic Prado
Dr. Catherine Roullier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Halogenated marine secondary metabolites
  • Ecological roles
  • Metabolomic studies
  • Bioengineering
  • Genome Mining

Published Papers (1 paper)

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Open AccessArticle
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
Mar. Drugs 2018, 16(9), 316; https://doi.org/10.3390/md16090316 - 06 Sep 2018
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for (+)-aeroplysinin-1 in endothelial cells. The sequential use of 2D-electrophoresis and MALDI-TOF-TOF/MS allowed [...] Read more.
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for (+)-aeroplysinin-1 in endothelial cells. The sequential use of 2D-electrophoresis and MALDI-TOF-TOF/MS allowed us to identify several differentially expressed proteins. Four of these proteins were involved in redox processes and were validated by Western blot. The effects of (+)-aeroplysinin-1 were further studied by testing the effects of the treatment with this compound on the activity of several anti- and pro-oxidant enzymes, as well as on transcription factors involved in redox homeostasis. Finally, changes in the levels of total reactive oxygen species and mitochondrial membrane potential induced by endothelial cell treatments with (+)-aeroplysinin-1 were also determined. Taken altogether, these findings show that (+)-aeroplysinin-1 has multiple targets involved in endothelial cell redox regulation. Full article
(This article belongs to the Special Issue Halogenated Metabolites)
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