Pro-Apoptotic Activity of French Polynesian Padina pavonica Extract on Human Osteosarcoma Cells
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Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018–2022), Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy
2
Institute of Cellular Pharmacology (ICP Concepts Ltd.), F24, Triq Valletta, Mosta Technopark, MST 3000 Mosta, Malta
*
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(12), 504; https://doi.org/10.3390/md16120504
Received: 7 November 2018
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Revised: 6 December 2018
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Accepted: 11 December 2018
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Published: 13 December 2018
(This article belongs to the Special Issue Seaweeds Secondary Metabolites: Successes in and/or Probable Therapeutic Applications)
Recently, seaweeds and their extracts have attracted great interest in the pharmaceutical industry as a source of bioactive compounds. Studies have demonstrated the cytotoxic activity of macroalgae towards different types of cancer cell models, and their consumption has been suggested as a chemo-preventive agent against several cancers such as breast, cervix and colon cancers. Reports relevant to the chemical properties of brown algae Padina sp. are limited and those accompanied to a comprehensive evaluation of the biological activity on osteosarcoma (OS) are non existent. In this report, we explored the chemical composition of French Polynesian Padina pavonica extract (EPP) by spectrophotometric assays (total phenolic, flavonoid and tannin content, and antioxidant activity) and by gas chromatography-mass spectrometry (GC-MS) analysis, and provided EPP lipid and sterols profiles. Several compounds with relevant biological activity were also identified that suggest interesting pharmacological and health-protecting effects for EPP. Moreover, we demonstrated that EPP presents good anti-proliferative and pro-apoptotic activities against two OS cell lines, SaOS-2 and MNNG, with different cancer-related phenotypes. Finally, our data suggest that EPP might target different properties associated with cancer development and aggressiveness.
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Keywords:
Padina pavonica; osteosarcoma; apoptosis; algae; chemo-preventive agent; phytol; fucosterol; fatty acid
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MDPI and ACS Style
Bernardini, G.; Minetti, M.; Polizzotto, G.; Biazzo, M.; Santucci, A. Pro-Apoptotic Activity of French Polynesian Padina pavonica Extract on Human Osteosarcoma Cells. Mar. Drugs 2018, 16, 504. https://doi.org/10.3390/md16120504
AMA Style
Bernardini G, Minetti M, Polizzotto G, Biazzo M, Santucci A. Pro-Apoptotic Activity of French Polynesian Padina pavonica Extract on Human Osteosarcoma Cells. Marine Drugs. 2018; 16(12):504. https://doi.org/10.3390/md16120504
Chicago/Turabian StyleBernardini, Giulia, Mariagiulia Minetti, Giuseppe Polizzotto, Manuele Biazzo, and Annalisa Santucci. 2018. "Pro-Apoptotic Activity of French Polynesian Padina pavonica Extract on Human Osteosarcoma Cells" Marine Drugs 16, no. 12: 504. https://doi.org/10.3390/md16120504
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