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Mar. Drugs 2015, 13(5), 3103-3115;

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia
Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Received: 23 February 2015 / Revised: 2 May 2015 / Accepted: 5 May 2015 / Published: 19 May 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
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Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages. View Full-Text
Keywords: soft coral; Capnella sp.; Nephtheidae; sesquiterpenoids; bicyclogermacrene soft coral; Capnella sp.; Nephtheidae; sesquiterpenoids; bicyclogermacrene

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Phan, C.-S.; Ng, S.-Y.; Kim, E.-A.; Jeon, Y.-J.; Palaniveloo, K.; Vairappan, C.S. Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.. Mar. Drugs 2015, 13, 3103-3115.

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