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Mar. Drugs 2014, 12(8), 4677-4692;

New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea

School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Biological Science & Technology, Mei Ho University, Pingtung 912, Taiwan
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Author to whom correspondence should be addressed.
Received: 28 May 2014 / Revised: 24 July 2014 / Accepted: 24 July 2014 / Published: 22 August 2014
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Ten new briarane diterpenoids, briaviolides A–J (110), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H–1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/ Cytochalasin B (fMLP/CB). View Full-Text
Keywords: Briareum violacea; briarane diterpenoids; briaviolides; anti-inflammatory activities Briareum violacea; briarane diterpenoids; briaviolides; anti-inflammatory activities

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Liaw, C.-C.; Cheng, Y.-B.; Lin, Y.-S.; Kuo, Y.-H.; Hwang, T.-L.; Shen, Y.-C. New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea. Mar. Drugs 2014, 12, 4677-4692.

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