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Volume 47
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10.3390/cimb47120977
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Genome-Wide Identification and Characterization of the PP2C Gene Family in Gossypium barbadense Reveals Potential Candidates for Breeding Improved Stress Resistance, Fiber Character, and Early Maturing Cotton Varieties

by
Nan Zhao
†,
Weiran Wang
†,
Zixin Zhou
,
Meng Wang
,
Caixia Li
,
Lingfang Ran
,
Yaohua Li
,
Jianping Li
,
Jiahui Zhu
,
Zhiqing Liu
,
Yifan Wang
,
Yahui Deng
,
Jing Yang
,
Alifu Aierxi
* and
Jie Kong
*
Cotton Research Institute, Xinjiang Uyghur Autonomous Region Academy of Agricultural Sciences (National Cotton Engineering Technology Research Center), Urumqi 830091, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2025, 47(12), 977; https://doi.org/10.3390/cimb47120977
Submission received: 17 October 2025 / Revised: 14 November 2025 / Accepted: 20 November 2025 / Published: 24 November 2025
(This article belongs to the Section Molecular Plant Sciences)
Versions Notes

Abstract

The protein phosphatase 2C (PP2C) gene family plays vital roles in plant growth and stress responses, yet remains inadequately characterized in cotton, particularly in Gossypium barbadense renowned for its superior fiber quality. Here, we identified 152 GbPP2Cs in Gossypium barbadense through genome-wide analysis and comparative genomics with three related cotton species (G. arboreum, G. raimondii, and G. hirsutum), identifying 105, 105, and 204 GbPP2Cs, respectively. GbPP2Cs show uneven chromosomal distribution with notable clustering on A05, evolutionary conservation in gene structure and motif composition, and predominant nuclear/chloroplast localization. Phylogenetic analysis classified them into 15 subfamilies showing conserved evolution. Protein enrichment revealed 15 GbPP2Cs involved in mitogen-activated protein kinase (MAPK) and hormone signaling pathways. Expression profiling revealed distinct members responsive to biotic/abiotic stresses, fiber development stages, and maturity. Notably, we discovered potential pleiotropic regulators including two genes (Gbar_D13G012000 and Gbar_A13G012360) co-regulating lint percentage and disease resistance, GbAIP1 coordinating fiber length-strength trade-off, and GbPP2C59 as a maturity negative candidate. These findings provide valuable genetic resources for cotton improvement.
Keywords: PP2C gene family; Gossypium barbadense; stress resistance; fiber character; early maturity PP2C gene family; Gossypium barbadense; stress resistance; fiber character; early maturity

Share and Cite

MDPI and ACS Style

Zhao, N.; Wang, W.; Zhou, Z.; Wang, M.; Li, C.; Ran, L.; Li, Y.; Li, J.; Zhu, J.; Liu, Z.; et al. Genome-Wide Identification and Characterization of the PP2C Gene Family in Gossypium barbadense Reveals Potential Candidates for Breeding Improved Stress Resistance, Fiber Character, and Early Maturing Cotton Varieties. Curr. Issues Mol. Biol. 2025, 47, 977. https://doi.org/10.3390/cimb47120977

AMA Style

Zhao N, Wang W, Zhou Z, Wang M, Li C, Ran L, Li Y, Li J, Zhu J, Liu Z, et al. Genome-Wide Identification and Characterization of the PP2C Gene Family in Gossypium barbadense Reveals Potential Candidates for Breeding Improved Stress Resistance, Fiber Character, and Early Maturing Cotton Varieties. Current Issues in Molecular Biology. 2025; 47(12):977. https://doi.org/10.3390/cimb47120977

Chicago/Turabian Style

Zhao, Nan, Weiran Wang, Zixin Zhou, Meng Wang, Caixia Li, Lingfang Ran, Yaohua Li, Jianping Li, Jiahui Zhu, Zhiqing Liu, and et al. 2025. "Genome-Wide Identification and Characterization of the PP2C Gene Family in Gossypium barbadense Reveals Potential Candidates for Breeding Improved Stress Resistance, Fiber Character, and Early Maturing Cotton Varieties" Current Issues in Molecular Biology 47, no. 12: 977. https://doi.org/10.3390/cimb47120977

APA Style

Zhao, N., Wang, W., Zhou, Z., Wang, M., Li, C., Ran, L., Li, Y., Li, J., Zhu, J., Liu, Z., Wang, Y., Deng, Y., Yang, J., Aierxi, A., & Kong, J. (2025). Genome-Wide Identification and Characterization of the PP2C Gene Family in Gossypium barbadense Reveals Potential Candidates for Breeding Improved Stress Resistance, Fiber Character, and Early Maturing Cotton Varieties. Current Issues in Molecular Biology, 47(12), 977. https://doi.org/10.3390/cimb47120977

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