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Current Issues in Molecular Biology, Volume 46, Issue 4

April 2024 - 59 articles

Cover Story: Major tumor-suppressor genes such as TP53, CDKN2A and SMAD4 have been associated with pancreatic cancer. Each gene’s role, prevalence and impact on tumor development and progression are analyzed, focusing on the intricate molecular landscape of pancreatic cancer. Their prognostic significance seems promising. Potential targeted therapies tailored to these molecular signatures are under investigation. Literature findings highlight the importance of genomic analyses for risk assessment, early detection and the design of personalized treatment approaches in pancreatic cancer. View this paper
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Articles (59)

  • Article
  • Open Access
5 Citations
2,957 Views
11 Pages

Enhancing Yield and Improving Grain Quality in Japonica Rice: Targeted EHD1 Editing via CRISPR-Cas9 in Low-Latitude Adaptation

  • Jian Song,
  • Liqun Tang,
  • Honghuan Fan,
  • Xiaozheng Xu,
  • Xinlu Peng,
  • Yongtao Cui and
  • Jianjun Wang

The “Indica to Japonica” initiative in China focuses on adapting Japonica rice varieties from the northeast to the unique photoperiod and temperature conditions of lower latitudes. While breeders can select varieties for their adaptabilit...

  • Article
  • Open Access
1,729 Views
12 Pages

Despite present antiviral agents that can effectively work against HIV-1 replication, side effects and drug resistance have pushed researchers toward novel approaches. In this context, there is a continued focus on discovering new and more effective...

  • Article
  • Open Access
1 Citations
2,108 Views
16 Pages

Analysis of microRNA Expression Profiles in Broiler Muscle Tissues by Feeding Different Levels of Guanidinoacetic Acid

  • Mengqian Liu,
  • Mengyuan Li,
  • Jinrui Ruan,
  • Junjing Jia,
  • Changrong Ge and
  • Weina Cao

The aim of this study was to explore the molecular mechanisms through which different levels of GAA affect chicken muscle development by influencing miRNA expression, to lay a theoretical foundation for the identification of key functional small RNAs...

  • Article
  • Open Access
2,232 Views
19 Pages

Establishing a multi-enzyme synergistic lignocellulosic biodegradation system using lytic polysaccharide monooxygenase (LPMO) and polyphenol oxidases is vital for efficiently utilizing plant biomass waste, ultimately benefiting the carbon cycle and p...

  • Article
  • Open Access
2 Citations
1,676 Views
18 Pages

Artemia is a widely distributed small aquatic crustacean, renowned for its ability to enter a state of embryonic diapause. The embryonic diapause termination (EDT) is closely linked to environmental cues, but the precise underlying mechanisms remain...

  • Review
  • Open Access
7 Citations
3,829 Views
36 Pages

The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis

  • Kajetan Kiełbowski,
  • Wiktoria Stańska,
  • Estera Bakinowska,
  • Marcin Rusiński and
  • Andrzej Pawlik

Alarmins are immune-activating factors released after cellular injury or death. By secreting alarmins, cells can interact with immune cells and induce a variety of inflammatory responses. The broad family of alarmins involves several members, such as...

  • Article
  • Open Access
9 Citations
5,539 Views
14 Pages

Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models

  • Dorota Bęben,
  • Oliwia Siwiela,
  • Anna Szyjka,
  • Michał Graczyk,
  • Daniel Rzepka,
  • Ewa Barg and
  • Helena Moreira

Phytocannabinoids, compounds found in Cannabis sativa L., are used in oncology and palliative care to reduce the adverse reactions of standard therapies. Cancer patients use formulations of Cannabis sativa L. to manage the anxiety, pain, and nausea a...

  • Article
  • Open Access
2 Citations
2,041 Views
16 Pages

Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating the signaling route o...

  • Article
  • Open Access
2 Citations
2,184 Views
15 Pages

Microbiome Sex-Related Diversity in Non-Muscle-Invasive Urothelial Bladder Cancer

  • Konrad Bilski,
  • Natalia Żeber-Lubecka,
  • Maria Kulecka,
  • Michalina Dąbrowska,
  • Aneta Bałabas,
  • Jerzy Ostrowski,
  • Aleksandra Dobruch and
  • Jakub Dobruch

Sex-specific discrepancies in bladder cancer (BCa) are reported, and new studies imply that microbiome may partially explain the diversity. We aim to provide characterization of the bladder microbiome in both sexes diagnosed with non-muscle-invasive...

  • Article
  • Open Access
4 Citations
3,024 Views
16 Pages

Association between KRAS and PIK3CA Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line

  • Kosuke Kanno,
  • Kentaro Nakayama,
  • Sultana Razia,
  • Sohel Hasibul Islam,
  • Zahan Umme Farzana,
  • Shahataj Begum Sonia,
  • Hitomi Yamashita,
  • Masako Ishikawa,
  • Tomoka Ishibashi and
  • Kayo Imamura
  • + 2 authors

Although endometriosis is a benign disease, it is associated with cancer-related gene mutations, such as KRAS or PIK3CA. Endometriosis is associated with elevated levels of inflammatory factors that cause severe pain. In a previous study, we demonstr...

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Curr. Issues Mol. Biol. - ISSN 1467-3045