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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Cellular Responses to Tumor Necrosis Factor

by
Zheng-gang Liu
and
Jiahuai Han
*
1
Cell and Cancer Biology Branch, Center of Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
2
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pones Road, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2001, 3(4), 79-90; https://doi.org/10.21775/cimb.003.079
Submission received: 15 May 2001 / Revised: 3 August 2001 / Accepted: 6 September 2001 / Published: 1 October 2001
Versions Notes

Abstract

TNF is a proinflammatory cytokine that plays an important role in many physiological and pathological conditions through the regulation of immunological reactions. Many of TNF functions have been proven to be cell type-specific, and the specificity of TNF- induced cellular responses in a given cell is determined by the specific intracellular signaling pathways that are activated by TNF. Although current information is insufficient to sort out how the cell type specificity is controlled by the different intracellular signaling pathways, a number of signaling pathways that are commonly activated in many types of cells by TNF have been revealed. This review weighs the current knowledge of these TNF-induced signaling pathways.

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MDPI and ACS Style

Liu, Z.-g.; Han, J. Cellular Responses to Tumor Necrosis Factor. Curr. Issues Mol. Biol. 2001, 3, 79-90. https://doi.org/10.21775/cimb.003.079

AMA Style

Liu Z-g, Han J. Cellular Responses to Tumor Necrosis Factor. Current Issues in Molecular Biology. 2001; 3(4):79-90. https://doi.org/10.21775/cimb.003.079

Chicago/Turabian Style

Liu, Zheng-gang, and Jiahuai Han. 2001. "Cellular Responses to Tumor Necrosis Factor" Current Issues in Molecular Biology 3, no. 4: 79-90. https://doi.org/10.21775/cimb.003.079

APA Style

Liu, Z.-g., & Han, J. (2001). Cellular Responses to Tumor Necrosis Factor. Current Issues in Molecular Biology, 3(4), 79-90. https://doi.org/10.21775/cimb.003.079

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