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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism

by
Bruno Lamontagne
,
Stéphanie Larose
,
Jim Boulanger
and
Sherif Abou Elela
*
Département de Microbiologie et d’Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2001, 3(4), 71-78; https://doi.org/10.21775/cimb.003.071
Submission received: 16 May 2001 / Revised: 2 August 2001 / Accepted: 3 September 2001 / Published: 1 October 2001
Versions Notes

Abstract

The last few years have witnessed the appreciation of dsRNA as a regulator of gene expression, a potential antiviral agent, and a tumor suppressor. However, in spite of these clear effects on the cell function, the mechanism that controls dsRNA maturation and stability remains unknown. Recently, the discovery of eukaryotic orthologues of the bacterial dsRNA specific ribonuclease III (RNase III) suggested a central role for these enzymes in the regulation of dsRNA and eukaryotic RNA metabolism in general. This article reviews the structure-function features of the eukaryotic RNase III family and their roles in dsRNA metabolism with an emphasis on the yeast RNase III. Yeast RNase III is involved in the maturation of the majority of snRNAs, snoRNAs, and rRNA. In addition, perturbation of the expression level of yeast RNase III alters meiosis and causes sterility. These basic functions of the yeast RNase III appear to be widely conserved which makes it a good model to understand the importance of eukaryotic dsRNA metabolism.

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MDPI and ACS Style

Lamontagne, B.; Larose, S.; Boulanger, J.; Elela, S.A. The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism. Curr. Issues Mol. Biol. 2001, 3, 71-78. https://doi.org/10.21775/cimb.003.071

AMA Style

Lamontagne B, Larose S, Boulanger J, Elela SA. The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism. Current Issues in Molecular Biology. 2001; 3(4):71-78. https://doi.org/10.21775/cimb.003.071

Chicago/Turabian Style

Lamontagne, Bruno, Stéphanie Larose, Jim Boulanger, and Sherif Abou Elela. 2001. "The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism" Current Issues in Molecular Biology 3, no. 4: 71-78. https://doi.org/10.21775/cimb.003.071

APA Style

Lamontagne, B., Larose, S., Boulanger, J., & Elela, S. A. (2001). The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism. Current Issues in Molecular Biology, 3(4), 71-78. https://doi.org/10.21775/cimb.003.071

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