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Pharmaceuticals, Volume 5, Issue 10

October 2012 - 8 articles

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Articles (8)

  • Review
  • Open Access
43 Citations
12,076 Views
19 Pages

Advances in Drug Design Based on the Amino Acid Approach: Taurine Analogues for the Treatment of CNS Diseases

  • Man Chin Chung,
  • Pedro Malatesta,
  • Priscila Longhin Bosquesi,
  • Paulo Renato Yamasaki,
  • Jean Leandro dos Santos and
  • Ednir Oliveira Vizioli

23 October 2012

Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the amino acid taurine (2-aminoe...

  • Article
  • Open Access
20 Citations
8,195 Views
8 Pages

Norethindrone Acetate in the Medical Management of Adenomyosis

  • Ozgul Muneyyirci-Delale,
  • Ashadeep Chandrareddy,
  • Siddhi Mankame,
  • Nanna Osei-Tutu and
  • Hans von Gizycki

22 October 2012

The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dys...

  • Review
  • Open Access
64 Citations
13,493 Views
17 Pages

16 October 2012

In neuronal systems, the health and activity of mitochondria and synapses are tightly coupled. For this reason, it has been postulated that mitochondrial abnormalities may, at least in part, drive neurodegeneration in conditions such as Alzheimer&rsq...

  • Article
  • Open Access
74 Citations
8,352 Views
11 Pages

Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors

  • Hiroyuki Taki,
  • Takanori Kanazawa,
  • Fuminari Akiyama,
  • Yuuki Takashima and
  • Hiroaki Okada

15 October 2012

The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delive...

  • Article
  • Open Access
17 Citations
8,986 Views
12 Pages

12 October 2012

The free –COOH present in NSAIDs is thought to be responsible for the GI irritation associated with all traditional NSAIDs. Exploitation of mutual prodrugs is an approach wherein the NSAID is covalently bounded to a second pharmacologically act...

  • Review
  • Open Access
13 Citations
7,505 Views
10 Pages

28 September 2012

Several important areas of interest intersect in a class of peptides characterized by their highly cationic and partly hydrophobic structure. These molecules have been called cell-penetrating peptides (CPPs) because they possess the ability to transl...

  • Article
  • Open Access
7 Citations
7,747 Views
16 Pages

28 September 2012

We have developed a method for estimating protein-ligand binding free energy (DG) based on the direct protein-ligand interaction obtained by a molecular dynamics simulation. Using this method, we estimated the DG value statistically by the average va...

  • Review
  • Open Access
13 Citations
16,771 Views
9 Pages

27 September 2012

The incidence of arthritis is increasing every year, as does the need for pain medication. The current work reviews an American Indian liniment that is traditionally used for pain therapy. The chemistry, therapeutic use and safety of the liniment are...