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Two Examples of RNA Aptamers with Antiviral Activity. Are Aptamers the Wished Antiviral Drugs?

Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), Av. del Conocimiento 17, PTS Granada, Armilla, 18016 Granada, Spain
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Pharmaceuticals 2020, 13(8), 157; https://doi.org/10.3390/ph13080157
Received: 9 June 2020 / Revised: 3 July 2020 / Accepted: 20 July 2020 / Published: 22 July 2020
The current Covid-19 pandemic has pointed out some major deficiencies of the even most advanced societies to fight against viral RNA infections. Once more, it has been demonstrated that there is a lack of efficient drugs to control RNA viruses. Aptamers are efficient ligands of a great variety of molecules including proteins and nucleic acids. Their specificity and mechanism of action make them very promising molecules for interfering with the function encoded in viral RNA genomes. RNA viruses store essential information in conserved structural genomic RNA elements that promote important steps for the consecution of the infective cycle. This work describes two well documented examples of RNA aptamers with antiviral activity against highly conserved structural domains of the HIV-1 and HCV RNA genome, respectively, performed in our laboratory. They are two good examples that illustrate the potential of the aptamers to fill the therapeutic gaps in the fight against RNA viruses. View Full-Text
Keywords: aptamers; antiviral RNAs; viral RNA genome; functional RNA domains; RNA tools; RNA structure/function aptamers; antiviral RNAs; viral RNA genome; functional RNA domains; RNA tools; RNA structure/function
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MDPI and ACS Style

Berzal-Herranz, A.; Romero-López, C. Two Examples of RNA Aptamers with Antiviral Activity. Are Aptamers the Wished Antiviral Drugs? Pharmaceuticals 2020, 13, 157. https://doi.org/10.3390/ph13080157

AMA Style

Berzal-Herranz A, Romero-López C. Two Examples of RNA Aptamers with Antiviral Activity. Are Aptamers the Wished Antiviral Drugs? Pharmaceuticals. 2020; 13(8):157. https://doi.org/10.3390/ph13080157

Chicago/Turabian Style

Berzal-Herranz, Alfredo; Romero-López, Cristina. 2020. "Two Examples of RNA Aptamers with Antiviral Activity. Are Aptamers the Wished Antiviral Drugs?" Pharmaceuticals 13, no. 8: 157. https://doi.org/10.3390/ph13080157

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