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Article

Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases

1
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
2
Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
3
Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 47; https://doi.org/10.3390/ph12020047
Received: 13 February 2019 / Revised: 15 March 2019 / Accepted: 19 March 2019 / Published: 29 March 2019
(This article belongs to the Special Issue Carbohydrates 2018)
Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases. View Full-Text
Keywords: sugars; iminosugars; glycosidase inhibition sugars; iminosugars; glycosidase inhibition
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MDPI and ACS Style

Estévez, J.C.; González, M.A.; Villaverde, M.C.; Hirokami, Y.; Kato, A.; Sussman, F.; Reza, D.; Estévez, R.J. Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases. Pharmaceuticals 2019, 12, 47. https://doi.org/10.3390/ph12020047

AMA Style

Estévez JC, González MA, Villaverde MC, Hirokami Y, Kato A, Sussman F, Reza D, Estévez RJ. Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases. Pharmaceuticals. 2019; 12(2):47. https://doi.org/10.3390/ph12020047

Chicago/Turabian Style

Estévez, Juan C., Marcos A. González, M. C. Villaverde, Yuki Hirokami, Atsushi Kato, Fredy Sussman, David Reza, and Ramón J. Estévez 2019. "Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases" Pharmaceuticals 12, no. 2: 47. https://doi.org/10.3390/ph12020047

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