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Article

Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology

1
Departament de Psicologia Bàsica, Sport Research Institute, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
2
ME/CFS Unit, Division of Rheumatology, Vall d’Hebron University Hospital Research Institute, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
3
Biomedical and Electronic Instrumentation Group, Department of Electronic Engineering, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain
4
Departament de Psiquiatria i Medicina Legal, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Marco Altini
Sensors 2021, 21(11), 3746; https://doi.org/10.3390/s21113746
Received: 20 April 2021 / Revised: 20 May 2021 / Accepted: 22 May 2021 / Published: 28 May 2021
In a previous study using mobile-health technology (mHealth), we reported a robust association between chronic fatigue symptoms and heart rate variability (HRV) in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study explores HRV analysis as an objective, non-invasive and easy-to-apply marker of ME/CFS using mHealth technology, and evaluates differential gender effects on HRV and ME/CFS core symptoms. In our methodology, participants included 77 ME/CFS patients (32 men and 45 women) and 44 age-matched healthy controls (19 men and 25 women), all self-reporting subjective scores for fatigue, sleep quality, anxiety, and depression, and neurovegetative symptoms of autonomic dysfunction. The inter-beat cardiac intervals are continuously monitored/recorded over three 5-min periods, and HRV is analyzed using a custom-made application (iOS) on a mobile device connected via Bluetooth to a wearable cardiac chest band. Male ME/CFS patients show increased scores compared with control men in all symptoms and scores of fatigue, and autonomic dysfunction, as with women in the first study. No differences in any HRV parameter appear between male ME/CFS patients and controls, in contrast to our findings in women. However, we have found negative correlations of ME/CFS symptomatology with cardiac variability (SDNN, RMSSD, pNN50, LF) in men. We have also found a significant relationship between fatigue symptomatology and HRV parameters in ME/CFS patients, but not in healthy control men. Gender effects appear in HF, LF/HF, and HFnu HRV parameters. A MANOVA analysis shows differential gender effects depending on the experimental condition in autonomic dysfunction symptoms and HF and HFnu HRV parameters. A decreased HRV pattern in ME/CFS women compared to ME/CFS men may reflect a sex-related cardiac autonomic dysfunction in ME/CFS illness that could be used as a predictive marker of disease progression. In conclusion, we show that HRV analysis using mHealth technology is an objective, non-invasive tool that can be useful for clinical prediction of fatigue severity, especially in women with ME/CFS. View Full-Text
Keywords: mHealth; heart rate variability; HRV; ME/CFS; myalgic encephalomyelitis; chronic fatigue syndrome; gender differences mHealth; heart rate variability; HRV; ME/CFS; myalgic encephalomyelitis; chronic fatigue syndrome; gender differences
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MDPI and ACS Style

Capdevila, L.; Castro-Marrero, J.; Alegre, J.; Ramos-Castro, J.; Escorihuela, R.M. Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology. Sensors 2021, 21, 3746. https://doi.org/10.3390/s21113746

AMA Style

Capdevila L, Castro-Marrero J, Alegre J, Ramos-Castro J, Escorihuela RM. Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology. Sensors. 2021; 21(11):3746. https://doi.org/10.3390/s21113746

Chicago/Turabian Style

Capdevila, Lluis, Jesús Castro-Marrero, José Alegre, Juan Ramos-Castro, and Rosa M. Escorihuela. 2021. "Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology" Sensors 21, no. 11: 3746. https://doi.org/10.3390/s21113746

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