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Sensors 2018, 18(2), 661; https://doi.org/10.3390/s18020661

Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA

1
School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China
2
School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China
*
Author to whom correspondence should be addressed.
Received: 1 February 2018 / Revised: 15 February 2018 / Accepted: 16 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Recent Advances in Nucleic Acid Sensors)
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Abstract

A porous silicon microcavity (PSiMC) with resonant peak wavelength of 635 nm was fabricated by electrochemical etching. Metal nanoparticles (NPs)/PSiMC enhanced fluorescence substrates were prepared by the electrostatic adherence of Au NPs that were distributed in PSiMC. The Au NPs/PSiMC device was used to characterize the target DNA immobilization and hybridization with its complementary DNA sequences marked with Rhodamine red (RRA). Fluorescence enhancement was observed on the Au NPs/PSiMC device substrate; and the minimum detection concentration of DNA ran up to 10 pM. The surface plasmon resonance (SPR) of the MC substrate; which is so well-positioned to improve fluorescence enhancement rather the fluorescence enhancement of the high reflection band of the Bragg reflector; would welcome such a highly sensitive in biosensor. View Full-Text
Keywords: porous silicon microcavity; gold nanoparticles; DNA; fluorescence porous silicon microcavity; gold nanoparticles; DNA; fluorescence
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Wang, J.; Jia, Z. Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA. Sensors 2018, 18, 661.

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