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Sensors 2017, 17(7), 1623; https://doi.org/10.3390/s17071623

The Application of Whole Cell-Based Biosensors for Use in Environmental Analysis and in Medical Diagnostics

1
Laboratory of Nanoscale Biosensing and Bioimaging, Instiute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuanxi Road, Wenzhou 325027, China
2
ARC Center of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia
*
Author to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 7 July 2017 / Accepted: 8 July 2017 / Published: 13 July 2017
(This article belongs to the Special Issue Whole Cell-Based Biosensors and Application)
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Abstract

Various whole cell-based biosensors have been reported in the literature for the last 20 years and these reports have shown great potential for their use in the areas of pollution detection in environmental and in biomedical diagnostics. Unlike other reviews of this growing field, this mini-review argues that: (1) the selection of reporter genes and their regulatory proteins are directly linked to the performance of celllular biosensors; (2) broad enhancements in microelectronics and information technologies have also led to improvements in the performance of these sensors; (3) their future potential is most apparent in their use in the areas of medical diagnostics and in environmental monitoring; and (4) currently the most promising work is focused on the better integration of cellular sensors with nano and micro scaled integrated chips. With better integration it may become practical to see these cells used as (5) real-time portable devices for diagnostics at the bedside and for remote environmental toxin detection and this in situ application will make the technology commonplace and thus as unremarkable as other ubiquitous technologies. View Full-Text
Keywords: whole cell biosensors; bacteria; living cells; detection; bioluminescence; sensors; reporters; environmental analysis; diagnosis whole cell biosensors; bacteria; living cells; detection; bioluminescence; sensors; reporters; environmental analysis; diagnosis
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Gui, Q.; Lawson, T.; Shan, S.; Yan, L.; Liu, Y. The Application of Whole Cell-Based Biosensors for Use in Environmental Analysis and in Medical Diagnostics. Sensors 2017, 17, 1623.

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