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Sensors 2016, 16(6), 747;

A Fast Strategy for Determination of Vitamin B9 in Food and Pharmaceutical Samples Using an Ionic Liquid-Modified Nanostructure Voltammetric Sensor

The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari 4815733971, Iran
Young Researchers and Elite Club, Ayatollah Amoli Branch, Islamic Azad University, Mazandaran 46351-43358, Iran
Department of Physics, Science and Research Branch, Islamic Azad University, Mazandaran 1477893855, Iran
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India
Department of Applied Chemistry, University of Johannesburg, Johannesburg 3204/6, South Africa
Key Laboratory of Applied Chemistry, Jiangxi Agricultural University, Nanchang 330045, China
Authors to whom correspondence should be addressed.
Academic Editors: Xiangqun Zeng, Michael T. Carter and Abdul Rehman
Received: 8 April 2016 / Revised: 6 May 2016 / Accepted: 19 May 2016 / Published: 24 May 2016
(This article belongs to the Special Issue Ionic Liquids)
Full-Text   |   PDF [2771 KB, uploaded 24 May 2016]   |  


Vitamin B9 or folic acid is an important food supplement with wide clinical applications. Due to its importance and its side effects in pregnant women, fast determination of this vitamin is very important. In this study we present a new fast and sensitive voltammetric sensor for the analysis of trace levels of vitamin B9 using a carbon paste electrode (CPE) modified with 1,3-dipropylimidazolium bromide (1,3-DIBr) as a binder and ZnO/CNTs nanocomposite as a mediator. The electro-oxidation signal of vitamin B9 at the surface of the 1,3-DIBr/ZnO/CNTs/CPE electrode appeared at 800 mV, which was about 95 mV less positive compared to the corresponding unmodified CPE. The oxidation current of vitamin B9 by square wave voltammetry (SWV) increased linearly with its concentration in the range of 0.08–650 μM. The detection limit for vitamin B9 was 0.05 μM. Finally, the utility of the new 1,3-DIBr/ZnO/CNTs/CPE electrode was tested in the determination of vitamin B9 in food and pharmaceutical samples. View Full-Text
Keywords: vitamin B9; ZnO/CNTs; ionic liquids; modified electrode vitamin B9; ZnO/CNTs; ionic liquids; modified electrode

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Khaleghi, F.; Irai, A.E.; Sadeghi, R.; Gupta, V.K.; Wen, Y. A Fast Strategy for Determination of Vitamin B9 in Food and Pharmaceutical Samples Using an Ionic Liquid-Modified Nanostructure Voltammetric Sensor. Sensors 2016, 16, 747.

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