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Sensors 2012, 12(7), 9791-9799;

Sensitivity of a Label-Free Guided-Mode Resonant Optical Biosensor with Different Modes

Engineering Research Center of Optical Instruments and Systems, Ministry of Education, Shanghai Key Lab of Modern Optical Systems, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China
Laboratory of Nanophotonic Functional Materials and Devices, Institute of Optoelectronic Materials and Technology, South China Normal University, Guangzhou 510631, China
Author to whom correspondence should be addressed.
Received: 4 June 2012 / Revised: 26 June 2012 / Accepted: 2 July 2012 / Published: 18 July 2012
(This article belongs to the Section Biosensors)
Full-Text   |   PDF [388 KB, uploaded 21 June 2014]


Sensitivity is a key factor in the performance of a sensor. To achieve maximum guided-mode resonant optical biosensor sensitivity, a comparison of biosensor sensitivity for Transverse Electric (TE) and Transverse Magnetic (TM) modes based on the distribution of electric fields is presented in this article. A label-free guided-mode resonant optical biosensor is designed using the quarter-wave anti-reflection method to reflect only a narrow band of wavelengths modulated by the adsorption of a biochemical material on the sensor surface at the reflected frequency. With the distribution of electric fields simulated according to the Rigorous Coupled Wave Analysis (RCWA) theory, it is found that the full width at half maximum of the TM mode is (~4 nm) narrower than that of the TE mode (~20 nm), and the surface sensitivity of the TE mode incident light is three times that of the TM mode. It is proposed in this article that the light mode plays an important role in the sensitivity of guided-mode resonant biosensors. View Full-Text
Keywords: sensitivity; biosensor; TE mode; TM mode; guided mode resonance (GMRF) sensitivity; biosensor; TE mode; TM mode; guided mode resonance (GMRF)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, Q.; Zhang, D.; Yang, H.; Tao, C.; Huang, Y.; Zhuang, S.; Mei, T. Sensitivity of a Label-Free Guided-Mode Resonant Optical Biosensor with Different Modes. Sensors 2012, 12, 9791-9799.

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