Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates
Abstract
:1. Introduction
2. Results
2.1. Synthesis of Chiral Acrylamides
2.2. Synthesis of Methyl 2-(4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates, 7 and 8
3. Discussion
4. Materials and Methods
4.1. General
4.2. Synthesis of Chiral Acrylamides
4.3. Synthesis of Methyl 2-(4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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entry | Base | Yield 7(a,b) | d.r. 7(a,b) |
---|---|---|---|
1 | DABCO (10 mol%) | 86% | 74:26 1 |
2 | DMAP (1 eq.) | not observed | ----- |
3 | DBU (10 mol%) | not observed | ----- |
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Pilotzi Xahuentitla, H.; Ortega Montes, J.G.; Gnecco Medina, D.H.; Terán Vázquez, J.L.; Hernández Núñez, E.; Orea Flores, M.L. Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates. Molbank 2024, 2024, M1903. https://doi.org/10.3390/M1903
Pilotzi Xahuentitla H, Ortega Montes JG, Gnecco Medina DH, Terán Vázquez JL, Hernández Núñez E, Orea Flores ML. Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates. Molbank. 2024; 2024(4):M1903. https://doi.org/10.3390/M1903
Chicago/Turabian StylePilotzi Xahuentitla, Hugo, Jesús Guadalupe Ortega Montes, Dino Hernán Gnecco Medina, Joel Luis Terán Vázquez, Emanuel Hernández Núñez, and Maria Laura Orea Flores. 2024. "Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates" Molbank 2024, no. 4: M1903. https://doi.org/10.3390/M1903