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N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
Nanotechnology Education and Research Center, South Ural State University, 76 Lenina Avenue, 454080 Chelyabinsk, Russia
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2021, 2021(3), M1253;
Received: 6 July 2021 / Accepted: 20 July 2021 / Published: 22 July 2021
(This article belongs to the Section Organic Synthesis)
A novel 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine was prepared by a rational and short two-step synthesis from commercially available ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate via 6-(chloromethyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. The structure of the synthesized compounds was established by elemental analysis, high-resolution mass-spectrometry, 1H, 13C-NMR and IR spectroscopy and mass-spectrometry. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a convenient intermediate for various disubstituted 1-methyl-1H-pyrazolo[3,4-d]pyrimidines, which may be of interest as substances with useful pharmacological properties. View Full-Text
Keywords: 1H-pyrazolo[3,4-d]pyrimidines; 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine; condensation; biological activity 1H-pyrazolo[3,4-d]pyrimidines; 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine; condensation; biological activity
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MDPI and ACS Style

Ogurtsov, V.A.; Rakitin, O.A. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine. Molbank 2021, 2021, M1253.

AMA Style

Ogurtsov VA, Rakitin OA. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine. Molbank. 2021; 2021(3):M1253.

Chicago/Turabian Style

Ogurtsov, Vladimir A., and Oleg A. Rakitin 2021. "4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine" Molbank 2021, no. 3: M1253.

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