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4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

1
N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
2
Nanotechnology Education and Research Center, South Ural State University, 76 Lenina Avenue, 454080 Chelyabinsk, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2021, 2021(3), M1253; https://doi.org/10.3390/M1253
Received: 6 July 2021 / Accepted: 20 July 2021 / Published: 22 July 2021
(This article belongs to the Section Organic Synthesis)
A novel 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine was prepared by a rational and short two-step synthesis from commercially available ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate via 6-(chloromethyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. The structure of the synthesized compounds was established by elemental analysis, high-resolution mass-spectrometry, 1H, 13C-NMR and IR spectroscopy and mass-spectrometry. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a convenient intermediate for various disubstituted 1-methyl-1H-pyrazolo[3,4-d]pyrimidines, which may be of interest as substances with useful pharmacological properties. View Full-Text
Keywords: 1H-pyrazolo[3,4-d]pyrimidines; 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine; condensation; biological activity 1H-pyrazolo[3,4-d]pyrimidines; 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine; condensation; biological activity
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MDPI and ACS Style

Ogurtsov, V.A.; Rakitin, O.A. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine. Molbank 2021, 2021, M1253. https://doi.org/10.3390/M1253

AMA Style

Ogurtsov VA, Rakitin OA. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine. Molbank. 2021; 2021(3):M1253. https://doi.org/10.3390/M1253

Chicago/Turabian Style

Ogurtsov, Vladimir A., and Oleg A. Rakitin 2021. "4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine" Molbank 2021, no. 3: M1253. https://doi.org/10.3390/M1253

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