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(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one

Ashburn Group, Mathematics, Natural, and Health Sciences Division, University of Hawai‘i West O‘ahu, 91-1001 Farrington Hwy, Kapolei, HI 96707, USA
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Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(1), M1184; https://doi.org/10.3390/M1184
Received: 8 December 2020 / Revised: 19 January 2021 / Accepted: 21 January 2021 / Published: 25 January 2021
(This article belongs to the Section Organic Synthesis)
Natural products known as chalcones show promise as chemotherapeutic agents for the neglected tropical disease known as leishmaniasis. Our objective is to synthesize new targets of opportunity that may lead to better treatments of this debilitating disease. Claisen-Schmidt condensation of 4-chlorobenzaldehyde with 2′-fluoro-4′-methoxyacetophenone using aqueous sodium hydroxide in ethanol yielded the novel compound (E)-3-(4-chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. The product was obtained in good yield and purity after recrystallization from ethyl acetate/hexane. With the known antiparasitic properties of halogenated chalcones, this novel compound is suitable for antileishmanial activity study. View Full-Text
Keywords: chalcone; synthesis; aldol; leishmaniasis; neglected tropical disease chalcone; synthesis; aldol; leishmaniasis; neglected tropical disease
MDPI and ACS Style

Bailey, N.; Atanes, A.; Ashburn, B.O. (E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. Molbank 2021, 2021, M1184. https://doi.org/10.3390/M1184

AMA Style

Bailey N, Atanes A, Ashburn BO. (E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. Molbank. 2021; 2021(1):M1184. https://doi.org/10.3390/M1184

Chicago/Turabian Style

Bailey, Nicholas; Atanes, Alaina; Ashburn, Bradley O. 2021. "(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one" Molbank 2021, no. 1: M1184. https://doi.org/10.3390/M1184

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