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Open AccessShort Note

6-Bromo-N-(3-(difluoromethyl)phenyl)quinolin-4-amine

1
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
UK National Crystallography Service, School of Chemistry, Highfield Campus, University of Southampton, Southampton SO17 1BJ, UK
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(4), M1161; https://doi.org/10.3390/M1161
Received: 9 October 2020 / Revised: 14 October 2020 / Accepted: 15 October 2020 / Published: 20 October 2020
A routine synthesis was performed to furnish the title compound which incorporates a versatile difluoromethyl group on the aniline substitution of a 4-anilinoquinoline kinase inhibitor motif. In addition, the small molecule crystal structure (of the HCl salt) was solved, which uncovered that the difluoromethyl group was disordered within the packing arrangement and also a 126.08(7)° out of plane character between the respective ring systems within the molecule. The compound was fully characterized with 1H/13C-NMR and high-resolution mass spectra (HRMS), with the procedures described. View Full-Text
Keywords: 4-anilino-quin(az)olines; hinge binder; conformational flexibility; kinase inhibitor design 4-anilino-quin(az)olines; hinge binder; conformational flexibility; kinase inhibitor design
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MDPI and ACS Style

Asquith, C.R.M.; Tizzard, G.J. 6-Bromo-N-(3-(difluoromethyl)phenyl)quinolin-4-amine. Molbank 2020, 2020, M1161.

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