Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (2)

Search Parameters:
Keywords = 4-anilino-quin(az)olines

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
7 pages, 1370 KB  
Short Note
6-Bromo-N-(3-(difluoromethyl)phenyl)quinolin-4-amine
by Christopher R. M. Asquith and Graham J. Tizzard
Molbank 2020, 2020(4), M1161; https://doi.org/10.3390/M1161 - 20 Oct 2020
Cited by 1 | Viewed by 4164
Abstract
A routine synthesis was performed to furnish the title compound which incorporates a versatile difluoromethyl group on the aniline substitution of a 4-anilinoquinoline kinase inhibitor motif. In addition, the small molecule crystal structure (of the HCl salt) was solved, which uncovered that the [...] Read more.
A routine synthesis was performed to furnish the title compound which incorporates a versatile difluoromethyl group on the aniline substitution of a 4-anilinoquinoline kinase inhibitor motif. In addition, the small molecule crystal structure (of the HCl salt) was solved, which uncovered that the difluoromethyl group was disordered within the packing arrangement and also a 126.08(7)° out of plane character between the respective ring systems within the molecule. The compound was fully characterized with 1H/13C-NMR and high-resolution mass spectra (HRMS), with the procedures described. Full article
Show Figures

Graphical abstract

6 pages, 1349 KB  
Short Note
6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine
by Christopher R. M. Asquith and Graham J. Tizzard
Molbank 2019, 2019(4), M1087; https://doi.org/10.3390/M1087 - 27 Oct 2019
Cited by 4 | Viewed by 3359
Abstract
We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed [...] Read more.
We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with 1H/13C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS). Full article
Show Figures

Graphical abstract

Back to TopTop