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Open AccessFeature PaperShort Note

2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole

1
School of Chemistry, National University of Ireland Galway, University Road, H91 TK33 Galway, Ireland
2
Department of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames KT1 2EE, UK
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1129; https://doi.org/10.3390/M1129
Received: 7 April 2020 / Revised: 24 April 2020 / Accepted: 29 April 2020 / Published: 1 May 2020
(This article belongs to the Special Issue Heterocycle Reactions)
Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-1H-benzimidazole to give the title compound in a 77% yield. A mechanism is proposed for the formation of this novel methylene fluoride. View Full-Text
Keywords: fluorine; nitrogen heterocycles; nitroxide; radicals; Selectfluor; TEMPO fluorine; nitrogen heterocycles; nitroxide; radicals; Selectfluor; TEMPO
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MDPI and ACS Style

Kielty, P.; Farràs, P.; Smith, D.A.; Aldabbagh, F. 2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole. Molbank 2020, 2020, M1129.

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