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Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones

1
Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P.O. Box 22006, Nicosia 1516, Cyprus
2
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
Department of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, Cyprus
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1128; https://doi.org/10.3390/M1128
Received: 14 April 2020 / Revised: 25 April 2020 / Accepted: 26 April 2020 / Published: 27 April 2020
(This article belongs to the Special Issue Heterocycle Reactions)
Reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-3-methylmorpholines (2 equiv), in THF, at ca. 20 °C gave (R) and (S)-3-chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones in 95 and 97% yields, respectively. The new compounds were fully characterized. View Full-Text
Keywords: substitution; heterocycle; thiadiazine; morpholine; chirality substitution; heterocycle; thiadiazine; morpholine; chirality
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MDPI and ACS Style

Kalogirou, A.S.; Asquith, C.R.M.; Koutentis, P.A. Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones. Molbank 2020, 2020, M1128.

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