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Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones

Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P.O. Box 22006, Nicosia 1516, Cyprus
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Department of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, Cyprus
Author to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1128;
Received: 14 April 2020 / Revised: 25 April 2020 / Accepted: 26 April 2020 / Published: 27 April 2020
(This article belongs to the Special Issue Heterocycle Reactions)
Reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-3-methylmorpholines (2 equiv), in THF, at ca. 20 °C gave (R) and (S)-3-chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones in 95 and 97% yields, respectively. The new compounds were fully characterized. View Full-Text
Keywords: substitution; heterocycle; thiadiazine; morpholine; chirality substitution; heterocycle; thiadiazine; morpholine; chirality
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MDPI and ACS Style

Kalogirou, A.S.; Asquith, C.R.M.; Koutentis, P.A. Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones. Molbank 2020, 2020, M1128.

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