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Open AccessShort Note

N-(2-Hydroxy-1,1-dimethylethyl)-3-methylbenzamide

Department of Chemistry, College of Science, Sultan Qaboos University, P.O. Box 36, Al Khoudh 123, Muscat, Oman
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Author to whom correspondence should be addressed.
Molbank 2020, 2020(1), M1099; https://doi.org/10.3390/M1099
Received: 14 November 2019 / Revised: 13 December 2019 / Accepted: 14 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Molecules from Side Reactions)
The title compound, N-(2-hydroxy-1,1-dimethylethyl)-3-methylbenzamide was synthesized by reacting 3-methylbenzoyl chloride or 3-methylbenzoic acid with 2-amino-2-methyl-1-propanol. In the present report, the synthesized target compound was fully characterized by various spectroscopic methods (1H NMR, 13C NMR, IR, GC-MS), its composition confirmed by elemental analysis, and its structure determined and confirmed by X-ray analysis. The importance of this compound lies in its possession of an N,O-bidentate directing group. Such a structural motif is potentially suitable for metal-catalyzed C–H bond functionalization reactions. View Full-Text
Keywords: organic synthesis; bidentate directing groups; benzamides; chelation assistance; bis-chelates; C–H bond functionalization; X-ray structure determination organic synthesis; bidentate directing groups; benzamides; chelation assistance; bis-chelates; C–H bond functionalization; X-ray structure determination
MDPI and ACS Style

Al Mamari, H.H.; Al Lawati, Y. N-(2-Hydroxy-1,1-dimethylethyl)-3-methylbenzamide. Molbank 2020, 2020, M1099.

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