N-(2-Hydroxy-1,1-dimethylethyl)-3-methylbenzamide
by
Hamad H. Al Mamari *
and Yousuf Al Lawati
Hamad H. Al Mamari * and Yousuf Al Lawati
Department of Chemistry, College of Science, Sultan Qaboos University, P.O. Box 36, Al Khoudh 123, Muscat, Oman
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(1), M1099; https://doi.org/10.3390/M1099
Received: 14 November 2019 / Revised: 13 December 2019 / Accepted: 14 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Molecules from Side Reactions)
The title compound, N-(2-hydroxy-1,1-dimethylethyl)-3-methylbenzamide was synthesized by reacting 3-methylbenzoyl chloride or 3-methylbenzoic acid with 2-amino-2-methyl-1-propanol. In the present report, the synthesized target compound was fully characterized by various spectroscopic methods (1H NMR, 13C NMR, IR, GC-MS), its composition confirmed by elemental analysis, and its structure determined and confirmed by X-ray analysis. The importance of this compound lies in its possession of an N,O-bidentate directing group. Such a structural motif is potentially suitable for metal-catalyzed C–H bond functionalization reactions.
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Keywords:
organic synthesis; bidentate directing groups; benzamides; chelation assistance; bis-chelates; C–H bond functionalization; X-ray structure determination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Al Mamari, H.H.; Al Lawati, Y. N-(2-Hydroxy-1,1-dimethylethyl)-3-methylbenzamide. Molbank 2020, 2020, M1099.
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