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Article

Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate

1
Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Atomistilor Street 405A, MG-7, 077125 Bucharest, Romania
2
Interdisciplinary School of Doctoral Studies, University of Bucharest, Șoseaua Panduri 90, 050663 Bucharest, Romania
3
Nanoscale Condensed Matter Laboratory, National Institute of Materials Physics, Atomistilor Street 405A, MG-7, 077125 Bucharest, Romania
4
Laboratory of Magnetism & Superconductivity, National Institute of Materials Physics, Atomistilor Street 405A, MG-7, 077125 Bucharest, Romania
5
SARA Pharm Solutions S.R.L., 266-268 Calea Rahovei, 050912 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Teresa Caccamo
Int. J. Mol. Sci. 2022, 23(7), 3975; https://doi.org/10.3390/ijms23073975
Received: 20 February 2022 / Revised: 24 March 2022 / Accepted: 31 March 2022 / Published: 2 April 2022
(This article belongs to the Special Issue Structural and Dynamical Characterization of Molecular Systems)
The effect of sodium thiosulfate (ST) on the photodegradation of azathioprine (AZA) was analyzed by UV-VIS spectroscopy, photoluminescence (PL), FTIR spectroscopy, Raman scattering, X-ray photoelectron (XPS) spectroscopy, thermogravimetry (TG) and mass spectrometry (MS). The PL studies highlighted that as the ST concentration increased from 25 wt.% to 75 wt.% in the AZA:ST mixture, the emission band of AZA gradual downshifted to 553, 542 and 530 nm. The photodegradation process of AZA:ST induced: (i) the emergence of a new band in the 320–400 nm range in the UV-VIS spectra of AZA and (ii) a change in the intensity ratio of the photoluminescence excitation (PLE) bands in the 280–335 and 335–430 nm spectral ranges. These changes suggest the emergence of new compounds during the photo-oxidation reaction of AZA with ST. The invoked photodegradation compounds were confirmed by studies of the Raman scattering, the FTIR spectroscopy and XPS spectroscopy through: (i) the downshift of the IR band of AZA from 1336 cm−1 to 1331 cm−1, attributed to N-C-N deformation in the purine ring; (ii) the change in the intensity ratio of the Raman lines peaking at 1305 cm−1 and 1330 cm−1 from 3.45 to 4.57, as the weight of ST in the AZA:ST mixture mass increased; and (iii) the emergence of a new band in the XPS O1s spectrum peaking at 531 eV, which was associated with the C=O bond. Through correlated studies of TG-MS, the main key fragments of ST-reacted AZA are reported. View Full-Text
Keywords: azathioprine; IR spectroscopy; photodegradation; Raman scattering; UV-VIS spectroscopy; photoluminescence azathioprine; IR spectroscopy; photodegradation; Raman scattering; UV-VIS spectroscopy; photoluminescence
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MDPI and ACS Style

Toulbe, N.; Smaranda, I.; Negrila, C.; Bartha, C.; Manta, C.M.; Baibarac, M. Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate. Int. J. Mol. Sci. 2022, 23, 3975. https://doi.org/10.3390/ijms23073975

AMA Style

Toulbe N, Smaranda I, Negrila C, Bartha C, Manta CM, Baibarac M. Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate. International Journal of Molecular Sciences. 2022; 23(7):3975. https://doi.org/10.3390/ijms23073975

Chicago/Turabian Style

Toulbe, N’ghaya, Ion Smaranda, Catalin Negrila, Cristina Bartha, Corina M. Manta, and Mihaela Baibarac. 2022. "Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate" International Journal of Molecular Sciences 23, no. 7: 3975. https://doi.org/10.3390/ijms23073975

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