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Article

N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor

Laboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology RAS, 111394 Moscow, Russia
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Academic Editors: Nunzianna Doti and Menotti Ruvo
Int. J. Mol. Sci. 2022, 23(10), 5752; https://doi.org/10.3390/ijms23105752
Received: 6 May 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 20 May 2022
An investigation of innate immunity receptors sheds light on the mechanisms of inflammation and associated immune reactions. One of the key immune regulators is the TREM-1 receptor, which is involved in both inflammation and antitumor immune response. In this article, we have obtained a new ligand for the TREM-1 receptor. The peptide, named N3, is a part of the innate immune protein PGLYRP1/Tag7. It is responsible for activating the TREM-1 signaling pathway. Here, we have demonstrated that the N3 peptide acts like other TREM-1 receptor ligands: its binding results in a mild inflammation response and appearance of cytotoxic lymphocytes. We have shown that cytotoxic populations of lymphocytes in N3 peptide-treated PBMCs are similar to those treated with Tag7 or Hsp70. We also determined the part of the N3 peptide responsible for binding to TREM-1. The resulting peptide (N9) consists of nine amino acids and can be considered as a potential peptide that blocks TREM-1 signaling. View Full-Text
Keywords: TREM-1; peptides; PGLYRP1/PGRP-S/Tag7; cytotoxicity; cytokines TREM-1; peptides; PGLYRP1/PGRP-S/Tag7; cytotoxicity; cytokines
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MDPI and ACS Style

Sharapova, T.N.; Ivanova, O.K.; Romanova, E.A.; Sashchenko, L.P.; Yashin, D.V. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. Int. J. Mol. Sci. 2022, 23, 5752. https://doi.org/10.3390/ijms23105752

AMA Style

Sharapova TN, Ivanova OK, Romanova EA, Sashchenko LP, Yashin DV. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. International Journal of Molecular Sciences. 2022; 23(10):5752. https://doi.org/10.3390/ijms23105752

Chicago/Turabian Style

Sharapova, Tatiana N., Olga K. Ivanova, Elena A. Romanova, Lidia P. Sashchenko, and Denis V. Yashin. 2022. "N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor" International Journal of Molecular Sciences 23, no. 10: 5752. https://doi.org/10.3390/ijms23105752

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