The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases
Abstract
:1. Introduction
2. The Region-Specific Metabolic Coupling
3. An Integrated Model of Synaptic Plasticity
3.1. Cellular and Extracellular Interactions
3.2. The Emergent Roles of the Extracellular Matrix and the Neurovascular Unit
4. The Burdensome Variable Energy Key Issue
5. Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Virtuoso, A.; Colangelo, A.M.; Maggio, N.; Fennig, U.; Weinberg, N.; Papa, M.; De Luca, C. The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases. Int. J. Mol. Sci. 2021, 22, 11304. https://doi.org/10.3390/ijms222111304
Virtuoso A, Colangelo AM, Maggio N, Fennig U, Weinberg N, Papa M, De Luca C. The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2021; 22(21):11304. https://doi.org/10.3390/ijms222111304
Chicago/Turabian StyleVirtuoso, Assunta, Anna Maria Colangelo, Nicola Maggio, Uri Fennig, Nitai Weinberg, Michele Papa, and Ciro De Luca. 2021. "The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases" International Journal of Molecular Sciences 22, no. 21: 11304. https://doi.org/10.3390/ijms222111304