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Review

CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis

1
División de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico
2
Doctorado en Genética Humana, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara 44340, Mexico
3
Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Ciencias Biomédicas, Universidad de Guadalajara, Guadalajara 44340, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: John Murphy, Kalpana Surendranath and Radhakrishnan Kanagaraj
Int. J. Mol. Sci. 2021, 22(20), 11056; https://doi.org/10.3390/ijms222011056
Received: 15 September 2021 / Revised: 6 October 2021 / Accepted: 10 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue RNA-Binding Proteins and Their Emerging Roles in Cancer)
Post-transcriptional modifications to coding and non-coding RNAs are unquestionably a pivotal way in which human mRNA and protein diversity can influence the different phases of a transcript’s life cycle. CELF (CUGBP Elav-like family) proteins are RBPs (RNA-binding proteins) with pleiotropic capabilities in RNA processing. Their responsibilities extend from alternative splicing and transcript editing in the nucleus to mRNA stability, and translation into the cytoplasm. In this way, CELF family members have been connected to global alterations in cancer proliferation and invasion, leading to their identification as potential tumor suppressors or even oncogenes. Notably, genetic variants, alternative splicing, phosphorylation, acetylation, subcellular distribution, competition with other RBPs, and ultimately lncRNAs, miRNAs, and circRNAs all impact CELF regulation. Discoveries have emerged about the control of CELF functions, particularly via noncoding RNAs, and CELF proteins have been identified as competing, antagonizing, and regulating agents of noncoding RNA biogenesis. On the other hand, CELFs are an intriguing example through which to broaden our understanding of the RBP/noncoding RNA regulatory axis. Balancing these complex pathways in cancer is undeniably pivotal and deserves further research. This review outlines some mechanisms of CELF protein regulation and their functional consequences in cancer physiology. View Full-Text
Keywords: CELF proteins; RNA-binding protein; noncoding RNA; cancer CELF proteins; RNA-binding protein; noncoding RNA; cancer
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MDPI and ACS Style

Nasiri-Aghdam, M.; Garcia-Garduño, T.C.; Jave-Suárez, L.F. CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis. Int. J. Mol. Sci. 2021, 22, 11056. https://doi.org/10.3390/ijms222011056

AMA Style

Nasiri-Aghdam M, Garcia-Garduño TC, Jave-Suárez LF. CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis. International Journal of Molecular Sciences. 2021; 22(20):11056. https://doi.org/10.3390/ijms222011056

Chicago/Turabian Style

Nasiri-Aghdam, Maryam, Texali C. Garcia-Garduño, and Luis F. Jave-Suárez 2021. "CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis" International Journal of Molecular Sciences 22, no. 20: 11056. https://doi.org/10.3390/ijms222011056

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