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Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model

1
NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Wszechnicy Piastowskiej 3, PL-61614 Poznań, Poland
2
Faculty of Physics, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 2, PL-61614 Poznań, Poland
3
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, PL-61614 Poznań, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 738; https://doi.org/10.3390/ijms22020738
Received: 20 December 2020 / Revised: 7 January 2021 / Accepted: 11 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue The Self-Assembly and Design of Polyfunctional Nanosystems 2.0)
The development of multifunctional drug delivery systems combining two or more nanoparticle-mediated therapies for efficient cancer treatment is highly desired. To face this challenge, a photothermally active polydopamine (PDA) nanoparticle-based platform was designed for the loading of chemotherapeutic drug and targeting of cancer cells. PDA spheres were first functionalized with polyamidoamine (PAMAM) dendrimers followed by the conjugation with polyethylene glycol (PEG) moieties and folic acid (FA) targeting ligand. The anticancer drug doxorubicin (DOX) was then absorbed on the particle surface. We performed the physico-chemical characterization of this versatile material and we assessed further its possible application in chemo- and photothermal therapy using liver cancer cell model. These nanoparticles exhibited high near-infrared photothermal conversion efficacy and allowed for loading of the drug, which upon release in specifically targeted cancer cells suppressed their growth. Using cell proliferation, membrane damage, apoptosis, and oxidative stress assays we demonstrated high performance of this nanosystem in cancer cell death induction, providing a novel promising approach for cancer therapy. View Full-Text
Keywords: polydopamine; dendrimers; PAMAM; combined therapy; cancer therapy; photothermal therapy polydopamine; dendrimers; PAMAM; combined therapy; cancer therapy; photothermal therapy
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MDPI and ACS Style

Grześkowiak, B.F.; Maziukiewicz, D.; Kozłowska, A.; Kertmen, A.; Coy, E.; Mrówczyński, R. Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model. Int. J. Mol. Sci. 2021, 22, 738. https://doi.org/10.3390/ijms22020738

AMA Style

Grześkowiak BF, Maziukiewicz D, Kozłowska A, Kertmen A, Coy E, Mrówczyński R. Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model. International Journal of Molecular Sciences. 2021; 22(2):738. https://doi.org/10.3390/ijms22020738

Chicago/Turabian Style

Grześkowiak, Bartosz F.; Maziukiewicz, Damian; Kozłowska, Agata; Kertmen, Ahmet; Coy, Emerson; Mrówczyński, Radosław. 2021. "Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model" Int. J. Mol. Sci. 22, no. 2: 738. https://doi.org/10.3390/ijms22020738

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