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Article

Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis

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Centre of Polymer Systems, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic
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Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic
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Faculty of Technology, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic
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Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic
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Department of Surface Engineering, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 501; https://doi.org/10.3390/ijms22020501
Received: 9 December 2020 / Revised: 23 December 2020 / Accepted: 29 December 2020 / Published: 6 January 2021
(This article belongs to the Section Molecular Biology)
The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial. View Full-Text
Keywords: conducting polymer; polypyrrole; biocompatibility; neurogenesis; stem cells conducting polymer; polypyrrole; biocompatibility; neurogenesis; stem cells
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MDPI and ACS Style

Skopalová, K.; Radaszkiewicz, K.A.; Kašpárková, V.; Stejskal, J.; Bober, P.; Junkar, I.; Mozetič, M.; Capáková, Z.; Lehocký, M.; Kašparová, M.; Pacherník, J.; Humpolíček, P. Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis. Int. J. Mol. Sci. 2021, 22, 501. https://doi.org/10.3390/ijms22020501

AMA Style

Skopalová K, Radaszkiewicz KA, Kašpárková V, Stejskal J, Bober P, Junkar I, Mozetič M, Capáková Z, Lehocký M, Kašparová M, Pacherník J, Humpolíček P. Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis. International Journal of Molecular Sciences. 2021; 22(2):501. https://doi.org/10.3390/ijms22020501

Chicago/Turabian Style

Skopalová, Kateřina, Katarzyna A. Radaszkiewicz, Věra Kašpárková, Jaroslav Stejskal, Patrycja Bober, Ita Junkar, Miran Mozetič, Zdenka Capáková, Marián Lehocký, Martina Kašparová, Jiří Pacherník, and Petr Humpolíček. 2021. "Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis" International Journal of Molecular Sciences 22, no. 2: 501. https://doi.org/10.3390/ijms22020501

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