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Article

Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats

1
School of Life Science, Huaiyin Normal University, 111 West Changjiang Road, Huai’an 223300, China
2
College of Food Science & Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
3
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Peter J. Little, Suowen Xu and Jianping Weng
Int. J. Mol. Sci. 2021, 22(18), 9823; https://doi.org/10.3390/ijms22189823
Received: 22 July 2021 / Revised: 31 August 2021 / Accepted: 6 September 2021 / Published: 11 September 2021
Food-derived oligosaccharides show promising therapeutic potential in lowering blood pressure (BP), but the mechanism is poorly understood. Recently, the potential role of gut microbiota (GM) in hypertension has been investigated, but the specific GM signature that may participate in hypertension remains unclear. To test the potassium alginate oligosaccharides (PAO) mechanism in lowering BP and specific microbial signature changes in altering GM, we administered various dosages of PAO in 40 spontaneously hypertensive rats for a duration of six weeks. We analyzed BP, sequenced the 16S ribosomal DNA gene in the cecum content, and gathered RNA-seq data in cardiac tissues. We showed that the oral administration of PAO could significantly decrease systolic BP and mean arterial pressure. Transcriptome analyses demonstrated that the protective effects of developing heart failure were accompanied by down-regulating of the Natriuretic Peptide A gene expression and by decreasing the concentrations of angiotensin II and atrial natriuretic peptide in plasma. In comparison to the Vehicle control, PAO could increase the microbial diversity by altering the composition of GM. PAO could also decrease the ratio of Firmicutes to Bacteroidetes by decreasing the abundance of Prevotella and Phascolarctobacterium bacteria. The favorable effect of PAO may be added to the positive influence of the abundance of major metabolites produced by Gram-negative bacteria in GM. We suggest that PAO caused changes in GM, and thus, they played an important role in preventing the development of cardiovascular disease. View Full-Text
Keywords: blood pressure; potassium alginate oligosaccharides; gut microbiota; heart failure blood pressure; potassium alginate oligosaccharides; gut microbiota; heart failure
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MDPI and ACS Style

Han, Z.-L.; Chen, M.; Fu, X.-D.; Yang, M.; Hrmova, M.; Zhao, Y.-H.; Mou, H.-J. Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats. Int. J. Mol. Sci. 2021, 22, 9823. https://doi.org/10.3390/ijms22189823

AMA Style

Han Z-L, Chen M, Fu X-D, Yang M, Hrmova M, Zhao Y-H, Mou H-J. Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats. International Journal of Molecular Sciences. 2021; 22(18):9823. https://doi.org/10.3390/ijms22189823

Chicago/Turabian Style

Han, Zhen-Lian, Meng Chen, Xiao-Dan Fu, Min Yang, Maria Hrmova, Yuan-Hui Zhao, and Hai-Jin Mou. 2021. "Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats" International Journal of Molecular Sciences 22, no. 18: 9823. https://doi.org/10.3390/ijms22189823

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