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Open AccessReview

Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?

1
Institute of Oncology Research, Faculty of Biomedical Sciences, USI, 6500 Bellinzona, Switzerland
2
Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
3
Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
4
Faculty of Biomedical Sciences, USI, 6900 Lugano, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 1060; https://doi.org/10.3390/ijms21031060
Received: 21 January 2020 / Revised: 31 January 2020 / Accepted: 3 February 2020 / Published: 5 February 2020
(This article belongs to the Special Issue mTOR in Human Diseases 2.0)
The activation of the PI3K/AKT/mTOR pathway is a main driver of cell growth, proliferation, survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive target for developing targeted anti-cancer drugs. There are plenty of preclinical data sustaining the anti-tumor activity of dual PI3K/mTOR inhibitors as single agents and in combination in lymphomas. Clinical responses, including complete remissions (especially in follicular lymphoma patients), are also observed in the very few clinical studies performed in patients that are affected by relapsed/refractory lymphomas or chronic lymphocytic leukemia. In this review, we summarize the literature on dual PI3K/mTOR inhibitors focusing on the lymphoma setting, presenting both the three compounds still in clinical development and those with a clinical program stopped or put on hold. View Full-Text
Keywords: TORC1; TORC2; PI3K; lymphoma; chronic lymphocytic leukemia TORC1; TORC2; PI3K; lymphoma; chronic lymphocytic leukemia
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MDPI and ACS Style

Tarantelli, C.; Lupia, A.; Stathis, A.; Bertoni, F. Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma? Int. J. Mol. Sci. 2020, 21, 1060.

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