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Open AccessArticle

Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species

1
Krasnoyarsk State Medical Academy, 660022 Krasnoyarsk, Russia
2
Institute of Biophysics SB RAS, Federal Research Center ‘Krasnoyarsk Science Center SB RAS’, 660036 Krasnoyarsk, Russia
3
Department of Chemistry, Moscow State University, 119991 Moscow, Russia
4
Biology Department, Irkutsk State University, 664003 Irkutsk, Russia
5
Biophysics Department, Siberian Federal University, Svobodny 79, 660041 Krasnoyarsk, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6783; https://doi.org/10.3390/ijms21186783
Received: 22 August 2020 / Revised: 10 September 2020 / Accepted: 15 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue Molecular Mechanisms of Responses to Low-Intensity Exposures)
The paper studies the combined effects of beta-emitting radionuclide tritium and Humic Substances (HS) on the marine unicellular microorganism—luminous bacteria—under conditions of low-dose radiation exposures (<0.04 Gy). Tritium was used as a component of tritiated water. Bacterial luminescence intensity was considered as a tested physiological parameter. The bioluminescence response of the marine bacteria to tritium corresponded to the “hormesis” model: it included stages of bioluminescence inhibition and activation, as well as the absence of the effect. HS were shown to decrease the inhibition and activation effects of tritium, similar to those of americium-241, alpha-emitting radionuclide, studied earlier. Correlations between the bioluminescence intensity and the content of Reactive Oxygen Species (ROS) were found in the radioactive bacterial suspensions. The results demonstrate an important role of HS in natural processes in the regions of low radioactive contamination: HS can mitigate radiotoxic effects and adaptive response of microorganisms to low-dose radioactive exposures. The involvement of ROS in these processes was demonstrated. View Full-Text
Keywords: tritium; humic substances; luminous marine bacterium; bioassay; detoxification; reactive oxygen species; toxicity; adaptive response; hormesis tritium; humic substances; luminous marine bacterium; bioassay; detoxification; reactive oxygen species; toxicity; adaptive response; hormesis
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Rozhko, T.V.; Kolesnik, O.V.; Badun, G.A.; Stom, D.I.; Kudryasheva, N.S. Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species. Int. J. Mol. Sci. 2020, 21, 6783.

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