Next Article in Journal
Pathological Responses of Cardiac Mitochondria to Burn Trauma
Next Article in Special Issue
Transcriptional Effects of Psychoactive Drugs on Genes Involved in Neurogenesis
Previous Article in Journal
Identification of Gastritis Subtypes by Convolutional Neuronal Networks on Histological Images of Antrum and Corpus Biopsies
Previous Article in Special Issue
Role of Excitatory Amino Acid Carrier 1 (EAAC1) in Neuronal Death and Neurogenesis After Ischemic Stroke
Open AccessReview

Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6653; https://doi.org/10.3390/ijms21186653
Received: 4 August 2020 / Revised: 3 September 2020 / Accepted: 8 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Mechanism of Adult Neurogenesis)
Establishing the existence and extent of neurogenesis in the adult brain throughout the animals including humans, would transform our understanding of how the brain works, and how to tackle brain damage and disease. Obtaining convincing, indisputable experimental evidence has generally been challenging. Here, we revise the state of this question in the fruit-fly Drosophila. The developmental neuroblasts that make the central nervous system and brain are eliminated, either through apoptosis or cell cycle exit, before the adult fly ecloses. Despite this, there is growing evidence that cell proliferation can take place in the adult brain. This occurs preferentially at, but not restricted to, a critical period. Adult proliferating cells can give rise to both glial cells and neurons. Neuronal activity, injury and genetic manipulation in the adult can increase the incidence of both gliogenesis and neurogenesis, and cell number. Most likely, adult glio- and neuro-genesis promote structural brain plasticity and homeostasis. However, a definitive visualisation of mitosis in the adult brain is still lacking, and the elusive adult progenitor cells are yet to be identified. Resolving these voids is important for the fundamental understanding of any brain. Given its powerful genetics, Drosophila can expedite discovery into mammalian adult neurogenesis in the healthy and diseased brain. View Full-Text
Keywords: Drosophila; neurogenesis; gliogenesis; brain; adult; cell proliferation; BrdU; EdU; FUCCI; PCNA; MARCM; stg; neuroblast; neural stem cell; progenitor; dMyc; miR-31a; MyD88; wek; Toll-2; Yki; eiger; TNF; inscutable; deadpan; plasticity; homeostasis; injury Drosophila; neurogenesis; gliogenesis; brain; adult; cell proliferation; BrdU; EdU; FUCCI; PCNA; MARCM; stg; neuroblast; neural stem cell; progenitor; dMyc; miR-31a; MyD88; wek; Toll-2; Yki; eiger; TNF; inscutable; deadpan; plasticity; homeostasis; injury
Show Figures

Figure 1

MDPI and ACS Style

Li, G.; Hidalgo, A. Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void. Int. J. Mol. Sci. 2020, 21, 6653. https://doi.org/10.3390/ijms21186653

AMA Style

Li G, Hidalgo A. Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void. International Journal of Molecular Sciences. 2020; 21(18):6653. https://doi.org/10.3390/ijms21186653

Chicago/Turabian Style

Li, Guiyi; Hidalgo, Alicia. 2020. "Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void" Int. J. Mol. Sci. 21, no. 18: 6653. https://doi.org/10.3390/ijms21186653

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop