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Article

Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation

1
Molecular Neurophysiology Research Group, Biomedical Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8566, Japan
2
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(13), 4772; https://doi.org/10.3390/ijms21134772
Received: 12 June 2020 / Revised: 26 June 2020 / Accepted: 3 July 2020 / Published: 5 July 2020
(This article belongs to the Special Issue The Mechanistic Link between Cell Therapy and Neurorehabilitation)
Indonesian ginger (Zingiber purpureum Rosc.), also known as Bangle, exhibits neurotrophic effects on cultured murine cortical neurons and in the adult mouse brain, but the underlying mechanisms remain unknown. Here, using human fetal neural stem cells (hfNSCs) as a model system for in vitro human neurogenesis, we show that Bangle extracts activate canonical WNT/β-catenin signaling. Bangle extract-treatment of hfNSCs not only promoted neuronal differentiation, but also accelerated neurite outgrowth from immature neurons. Furthermore, Bangle extracts induced expression of neurogenic genes and WNT signaling-target genes, and facilitated the accumulation of β-catenin in nuclei of hfNSC. Interestingly, altered histone modifications were also observed in Bangle-treated hfNSCs. Together, these findings demonstrate that Bangle contributes to hfNSC neurogenesis by WNT pathway and epigenetic regulation. View Full-Text
Keywords: neural stem cells; human neurogenesis; Zingiber purpureum; Banglene; WNT signaling; histone deacetylase neural stem cells; human neurogenesis; Zingiber purpureum; Banglene; WNT signaling; histone deacetylase
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MDPI and ACS Style

Hirano, K.; Kubo, M.; Fukuyama, Y.; Namihira, M. Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation. Int. J. Mol. Sci. 2020, 21, 4772. https://doi.org/10.3390/ijms21134772

AMA Style

Hirano K, Kubo M, Fukuyama Y, Namihira M. Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation. International Journal of Molecular Sciences. 2020; 21(13):4772. https://doi.org/10.3390/ijms21134772

Chicago/Turabian Style

Hirano, Kazumi, Miwa Kubo, Yoshiyasu Fukuyama, and Masakazu Namihira. 2020. "Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation" International Journal of Molecular Sciences 21, no. 13: 4772. https://doi.org/10.3390/ijms21134772

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