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Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

1
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3° (1113), Buenos Aires 1113, Argentina
2
Department of Chemistry, Faraday Building, Lancaster University, Lancaster, Lancashire LA1 4YB, UK
3
Materials Science Institute, Faraday Building, Lancaster University, Lancaster, Lancashire LA1 4YB, UK
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(13), 4724; https://doi.org/10.3390/ijms21134724
Received: 4 June 2020 / Revised: 28 June 2020 / Accepted: 30 June 2020 / Published: 2 July 2020
(This article belongs to the Collection Feature Papers in Materials Science)
Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues. View Full-Text
Keywords: stimuli-responsive materials; tissue engineering; drug delivery; biomaterials; thermoresponsive; pH-responsive; light-responsive; redox-responsive stimuli-responsive materials; tissue engineering; drug delivery; biomaterials; thermoresponsive; pH-responsive; light-responsive; redox-responsive
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MDPI and ACS Style

Municoy, S.; Álvarez Echazú, M.I.; Antezana, P.E.; Galdopórpora, J.M.; Olivetti, C.; Mebert, A.M.; Foglia, M.L.; Tuttolomondo, M.V.; Alvarez, G.S.; Hardy, J.G.; Desimone, M.F. Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery. Int. J. Mol. Sci. 2020, 21, 4724. https://doi.org/10.3390/ijms21134724

AMA Style

Municoy S, Álvarez Echazú MI, Antezana PE, Galdopórpora JM, Olivetti C, Mebert AM, Foglia ML, Tuttolomondo MV, Alvarez GS, Hardy JG, Desimone MF. Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery. International Journal of Molecular Sciences. 2020; 21(13):4724. https://doi.org/10.3390/ijms21134724

Chicago/Turabian Style

Municoy, Sofia, María I. Álvarez Echazú, Pablo E. Antezana, Juan M. Galdopórpora, Christian Olivetti, Andrea M. Mebert, María L. Foglia, María V. Tuttolomondo, Gisela S. Alvarez, John G. Hardy, and Martin F. Desimone. 2020. "Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery" International Journal of Molecular Sciences 21, no. 13: 4724. https://doi.org/10.3390/ijms21134724

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