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Open AccessArticle

Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production

Unidad de Inflamación Molecular y Cirugía Experimental, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(13), 4686;
Received: 6 May 2020 / Revised: 19 June 2020 / Accepted: 27 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Dissecting the Purinergic Signaling Puzzle)
The release of nucleotides during necrosis or apoptosis has been described to have both proinflammatory and anti-inflammatory effect on the surrounding cells. Here we describe how low concentrations of UTP and ATP applied during macrophage priming enhance IL-1β production when subsequently the NLRP3 inflammasome is activated in murine resident peritoneal macrophages. Deficiency or pharmacological inhibition of the purinergic receptor P2Y2 reverted the increase of IL-1β release induced by nucleotides. IL-1β increase was found dependent on the expression of Il1b gene and probably involving JNK activity. On the contrary, nucleotides decreased the production of a different proinflammatory cytokines such as TNF-α. These results suggest that nucleotides could shape the response of macrophages to obtain a unique proinflammatory signature that might be relevant in unrevealing specific inflammatory conditions. View Full-Text
Keywords: purinergic signaling; macrophages; inflammation; cytokines; extracellular nucleotides purinergic signaling; macrophages; inflammation; cytokines; extracellular nucleotides
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de la Rosa, G.; Gómez, A.I.; Baños, M.C.; Pelegrín, P. Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production. Int. J. Mol. Sci. 2020, 21, 4686.

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