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Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives

1
Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso
2
Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), 01 BP 216 Ouagadougou 01, Burkina Faso
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Université Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, France
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Université Norbert ZONGO, BP 376 Koudougou, Burkina Faso
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Département Biomédical et Santé Publique, Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3690; https://doi.org/10.3390/ijms21103690 (registering DOI)
Received: 30 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Molecular Biology of Nuclear Receptors 2.0)
The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their physiological activity through their respective nuclear receptors when the tumors relapse. Unfortunately, at some stage, both breast and prostate cancers become resistant to pharmacological treatments that aim to block their receptors, estrogen (ER) or androgen (AR) receptors, respectively. So far, antiestrogens and antiandrogens used in clinics have been designed based on their structural analogies with natural hormones, 17-β estradiol and dihydrotestosterone. Plants are a potential source of drug discovery and the development of new pharmacological compounds. The aim of this review article is to highlight the recent advances in the pharmacological modulation of androgen or estrogen levels, and their activity through their cognate nuclear receptors in prostate or breast cancer and the effects of some plants extracts. View Full-Text
Keywords: nuclear receptors; hormone-dependent tumors; prostate and breast cancers; plant extract derivatives; steroids nuclear receptors; hormone-dependent tumors; prostate and breast cancers; plant extract derivatives; steroids
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MDPI and ACS Style

Bayala, B.; Zoure, A.A.; Baron, S.; de Joussineau, C.; Simpore, J.; Lobaccaro, J.-M.A. Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives. Int. J. Mol. Sci. 2020, 21, 3690.

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