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Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections

by Shanhui Ren 1, Chan Ding 1,2,* and Yingjie Sun 1,*
1
Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, China
2
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou 225009, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3689; https://doi.org/10.3390/ijms21103689
Received: 13 March 2020 / Revised: 14 May 2020 / Accepted: 21 May 2020 / Published: 23 May 2020
Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and temporal separation of assembly reactions depends on accurate coordination among intracellular compartmentalization in multiple organelles. Here, we overview the rearrangement and morphology remodeling of virus-triggered intracellular organelles. Focus is given to the quality control of intracellular organelles, the hijacking of the modified organelle membranes by viruses, morphology remodeling for viral replication, and degradation of intracellular organelles by virus-triggered selective autophagy. Understanding the functional reprogram and morphological remodeling in the virus-organelle interplay can provide new insights into the development of broad-spectrum antiviral strategies. View Full-Text
Keywords: virus; intracellular organelles; rearrangement; remodeling; selective autophagy virus; intracellular organelles; rearrangement; remodeling; selective autophagy
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Ren, S.; Ding, C.; Sun, Y. Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections. Int. J. Mol. Sci. 2020, 21, 3689.

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