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Open AccessArticle

Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

1
Centre of Physics (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2
Physics Department and CICECO, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3641; https://doi.org/10.3390/ijms21103641
Received: 9 April 2020 / Revised: 6 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Curcumin in Health and Disease: New Knowledge)
Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release. View Full-Text
Keywords: magnetic nanoparticles; calcium-substituted magnesium ferrites; magnetoliposomes; curcumin release; cancer therapy magnetic nanoparticles; calcium-substituted magnesium ferrites; magnetoliposomes; curcumin release; cancer therapy
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Cardoso, B.D.; Rodrigues, A.R.O.; Almeida, B.G.; Amorim, C.O.; Amaral, V.S.; Castanheira, E.M.S.; Coutinho, P.J.G. Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release. Int. J. Mol. Sci. 2020, 21, 3641.

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