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Int. J. Mol. Sci. 2019, 20(8), 1860; https://doi.org/10.3390/ijms20081860

The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection

1
Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La Réunion, France
2
Laboratorio de Virologia Molecular, Instituto Carlos Chagas, ICC/FIOCRUZ/PR, Curitiba, Parana 81350-010, Brazil
3
Viral Genomics and Vaccination Unit, UMR CNRS 3569, Institut Pasteur, 75724 Paris, France
4
Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
5
Université Grenoble Alpes, SYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, INAC/CEA, 38000 Grenoble, France
*
Author to whom correspondence should be addressed.
Received: 12 March 2019 / Revised: 10 April 2019 / Accepted: 12 April 2019 / Published: 15 April 2019
(This article belongs to the Special Issue Natural Products against Viral Infections)
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Abstract

The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses. View Full-Text
Keywords: Zika virus; Dengue virus; antiviral activity; natural compounds; nutraceuticals; Psiloxylon mauritianum Zika virus; Dengue virus; antiviral activity; natural compounds; nutraceuticals; Psiloxylon mauritianum
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Clain, E.; Haddad, J.G.; Koishi, A.C.; Sinigaglia, L.; Rachidi, W.; Desprès, P.; N. Duarte dos Santos, C.; Guiraud, P.; Jouvenet, N.; El Kalamouni, C. The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection. Int. J. Mol. Sci. 2019, 20, 1860.

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