Next Article in Journal
Regulation Mechanism of MYC Family Transcription Factors in Jasmonic Acid Signalling Pathway on Taxol Biosynthesis
Previous Article in Journal
Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(8), 1842; https://doi.org/10.3390/ijms20081842

Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis

1
Department of Obstetrics-Gynaecology, Royal Oldham Hospital, Pennine Accute Trust, Oldham OL12JH, UK
2
3rd Department of Surgery, “AHEPA” University Hospital, Aristotle University of Thessaloniki, 55236 Thessaloniki, Greece
3
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece
4
Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 52236 Thessaloniki, Greece
5
Anesthesiology Department, “AHEPA” University Hospital, Aristotle University of Thessaloniki, 52236 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Received: 11 March 2019 / Revised: 8 April 2019 / Accepted: 12 April 2019 / Published: 14 April 2019
  |  
PDF [267 KB, uploaded 18 April 2019]

Abstract

The genetic and epigenetic factors that contribute to the malignant transformation of endometriosis are still under investigation. The objective of the present study was to investigate the genetic link between endometriosis and cancer by examining and correlating the latest clinical observations with biological experimental data. We collected updated evidence about the genetic relationship between endometriosis and cancers by conducting a comprehensive search of PubMed and Scopus databases, focusing on the papers published between January 2018 and January 2019. New insights into the mechanism of the malignant transformation of endometriosis have been published recently. The use of state-of-the-art techniques and methods, such as the genome-wide association study analysis and the weighted gene co-expression analysis, have significantly altered our understanding of the association between endometriosis and endometriosis-associated cancer development. Interestingly, the interactions formed between genes seem to play a pivotal role in the phenotypic expression of mutations. Therefore, the effect of single nucleotide polymorphisms and the function of the expression quantitative trait loci on genes’ expression have been the subject of many recent works. In addition, it has been discovered that genes, the mutations of which have been related to the development of endometriosis, play a role as hub genes. This may lead to new areas of research for understanding the mechanism of malignant transformation of the disease. Significant steps forward have been made towards the identification of factors that control the malignant transformation of endometriosis. Still, due to rarity of the event, a better-organized scheme for sampling on a global level should be adopted. View Full-Text
Keywords: malignant transformation; endometriosis; cancer; tumor; mutation; biomarker malignant transformation; endometriosis; cancer; tumor; mutation; biomarker
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sapalidis, K.; Machairiotis, N.; Zarogoulidis, P.; Vasilakaki, S.; Sardeli, C.; Koimtzis, G.; Pavlidis, E.; Katsaounis, A.; Giannakidis, D.; Michalopoulos, N.; Mantalobas, S.; Alexandrou, V.; Koulouris, C.; Amaniti, A.; Kesisoglou, I. Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis. Int. J. Mol. Sci. 2019, 20, 1842.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top