The Link Between Inflammaging and Degenerative Joint Diseases
by
Elena Rezuș 1,†, Anca Cardoneanu 1,†, Alexandra Burlui 1, Andrei Luca 2,*, Cătălin Codreanu 3, Bogdan Ionel Tamba 2,*, Gabriela-Dumitrița Stanciu 2, Nicoleta Dima 4, Codruța Bădescu 4 and Ciprian Rezuș 4
Elena Rezuș 1,†, Anca Cardoneanu 1,†, Alexandra Burlui 1, Andrei Luca 2,*, Cătălin Codreanu 3, Bogdan Ionel Tamba 2,*, Gabriela-Dumitrița Stanciu 2, Nicoleta Dima 4, Codruța Bădescu 4 and Ciprian Rezuș 4
1
Department of Rheumatology and Physiotherapy, “Grigore T. Popa’’ University of Medicine and Pharmacy Iași, University Street no. 16, 700115 Iași, Romania
2
Advanced Center for Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa’’ University of Medicine and Pharmacy Iași, Mihail Kogălniceanu Street no. 9-13, 700454 Iasi, Romania
3
Center for Rheumatic Diseases, “Carol Davila” University of Medicine and Pharmacy Bucharest, Eroii Sanitari no.8 Boulevard, 050474 Bucharest, Romania
4
Department of Internal Medicine, “Grigore T. Popa’’ University of Medicine and Pharmacy Iași, University Street no. 16, zip code 700115 Iași, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(3), 614; https://doi.org/10.3390/ijms20030614
Received: 24 December 2018 / Revised: 21 January 2019 / Accepted: 29 January 2019 / Published: 31 January 2019
(This article belongs to the Special Issue Inflammaging and Oxidative Stress in Aging and Age-Related Disorders)
Aging is an inevitable process in the human body that is associated with a multitude of systemic and localized changes. All these conditions have a common pathogenic mechanism characterized by the presence of a low-grade proinflammatory status. Inflammaging refers to all the processes that contribute to the occurrence of various diseases associated with aging such as frailty, atherosclerosis, Alzheimer’s disease, sarcopenia, type 2 diabetes, or osteoarthritis. Inflammaging is systemic, chronic, and asymptomatic. Osteoarthritis and many age-related degenerative joint diseases are correlated with aging mechanisms such as the presence of an inflammatory microenvironment and the impaired link between inflammasomes and autophagy. There is a close relationship between chondrocyte activity and local articular environment changes due to cell senescence, followed by secretion of inflammatory mediators. In addition, systemic inflammaging can lead to cartilage destruction, pain, disability, and an impaired quality of life. The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.
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Keywords:
inflammaging; osteoarthritis; chondrosenescence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Rezuș, E.; Cardoneanu, A.; Burlui, A.; Luca, A.; Codreanu, C.; Tamba, B.I.; Stanciu, G.-D.; Dima, N.; Bădescu, C.; Rezuș, C. The Link Between Inflammaging and Degenerative Joint Diseases. Int. J. Mol. Sci. 2019, 20, 614.
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