The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis
1
Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
2
Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Augustenburger Platz 1, 10117 Berlin, Germany
3
Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(19), 4820; https://doi.org/10.3390/ijms20194820
Received: 13 September 2019 / Revised: 25 September 2019 / Accepted: 26 September 2019 / Published: 28 September 2019
(This article belongs to the Special Issue Adipokines 2.0)
Sepsis represents a major global health burden. Early diagnosis of sepsis as well as guiding early therapeutic decisions in septic patients still represent major clinical challenges. In this context, a whole plethora of different clinical and serum-based markers have been tested regarding their potential for early detection of sepsis and their ability to stratify patients according to their probability to survive critical illness and sepsis. Adipokines represent a fast-growing class of proteins that have gained an increasing interest with respect to their potential to modulate immune responses in inflammatory and infectious diseases. We review current knowledge on the role of different adipokines in diagnostic work-up and risk stratification of sepsis as well as critical illness. We discuss recent data from animal models as well as from clinical studies and finally highlight the limitations of these analyses that currently prevent the use of adipokines as biomarkers in daily practice.
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Keywords:
critical illness; sepsis; adipokines; biomarker; prognosis; ICU
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Loosen, S.H.; Koch, A.; Tacke, F.; Roderburg, C.; Luedde, T. The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. Int. J. Mol. Sci. 2019, 20, 4820. https://doi.org/10.3390/ijms20194820
AMA Style
Loosen SH, Koch A, Tacke F, Roderburg C, Luedde T. The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. International Journal of Molecular Sciences. 2019; 20(19):4820. https://doi.org/10.3390/ijms20194820
Chicago/Turabian StyleLoosen, Sven H.; Koch, Alexander; Tacke, Frank; Roderburg, Christoph; Luedde, Tom. 2019. "The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis" Int. J. Mol. Sci. 20, no. 19: 4820. https://doi.org/10.3390/ijms20194820
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