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Chemerin and Cancer
Article

Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction?

by 1,2,3,4, 1,2,3,4, 1,2,3,4, 5, 1,2,3,4,5, 1,2,3,4 and 1,2,3,4,*
1
Institut National de la Recherche Agronomique Unité Mixte de Recherche Physiology Department, Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
2
Centre National de la Recherche Scientifique, Life Science Department Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
3
Université François Rabelais de Tours, F-37041 Tours, France
4
Institut Français du Cheval et de l’équitation F-37380 Nouzilly, France
5
Service de Médecine et Biologie de la Reproduction, CHRU Bretonneau, 2, boulevard Tonnellé, F-37044 Tours, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3778; https://doi.org/10.3390/ijms20153778
Received: 12 July 2019 / Revised: 29 July 2019 / Accepted: 31 July 2019 / Published: 2 August 2019
(This article belongs to the Special Issue Adipokines 2.0)
Adipokines are a potential link between reproduction and energy metabolism and could partly explain some infertilities related to some pathophysiology, such as polycystic ovary syndrome (PCOS). However, adipokines were predominantly assessed in blood samples, while very little is known concerning their variations in follicular fluid (FF) and ovarian granulosa cells (GCs) of PCOS women. Thus, the objectives of our study were to investigate adiponectin, chemerin, resistin, visfatin, omentin, and apelin ovarian expression in PCOS women in comparison with controls and women with only a polycystic ovary morphology. In total, 78 women undergoing an in vitro fertilization procedure were divided into three groups: 23 PCOS women, 28 women presenting only ≥12 follicles per ovary (ECHO group), and 27 control women. Each group almost equally included normal weight and obese women. Follicular fluid (FF) concentration and granulosa cells (GCs) mRNA expression of adipokines and their receptors were assessed by ELISA and RT-qPCR, respectively. Omentin levels in FF and GC were higher in PCOS than in ECHO and control women, while apelin expression was increased in both PCOS and ECHO groups. FF chemerin concentration was predominant in normal-weight PCOS women compared to BMI (Body Mass Index)-matched ECHO and control women, while GC mRNA levels were higher in the obese PCOS group than in the ECHO one. Compared to PCOS, ECHO women had increased FF adiponectin concentrations and lower plasma AMH levels. The FF concentration of all adipokines was higher in obese subjects except for adiponectin, predominant in normal-weight women. In conclusion, women with PCOS expressed higher GC chemerin and omentin, whereas the ECHO group presented higher levels of FF adiponectin and apelin and lower plasma AMH and LH concentrations. Chemerin, omentin, and apelin expression was differently regulated in women with PCOS, suggesting their possible role in follicular growth arrest and ovulatory dysfunction characterizing PCOS pathogenesis. View Full-Text
Keywords: adipokines; PCOS; polycystic ovary morphology; follicular fluid; human granulosa cells adipokines; PCOS; polycystic ovary morphology; follicular fluid; human granulosa cells
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MDPI and ACS Style

Bongrani, A.; Mellouk, N.; Rame, C.; Cornuau, M.; Guérif, F.; Froment, P.; Dupont, J. Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction? Int. J. Mol. Sci. 2019, 20, 3778. https://doi.org/10.3390/ijms20153778

AMA Style

Bongrani A, Mellouk N, Rame C, Cornuau M, Guérif F, Froment P, Dupont J. Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction? International Journal of Molecular Sciences. 2019; 20(15):3778. https://doi.org/10.3390/ijms20153778

Chicago/Turabian Style

Bongrani, Alice, Namya Mellouk, Christelle Rame, Marion Cornuau, Fabrice Guérif, Pascal Froment, and Joëlle Dupont. 2019. "Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction?" International Journal of Molecular Sciences 20, no. 15: 3778. https://doi.org/10.3390/ijms20153778

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