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Histone Deacetylase HDT1 is Involved in Stem Vascular Development in Arabidopsis

1,†, 1,†, 1,†, 1,†, 1, 1, 1, 1, 1, 1,2,* and 1,2
College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China
National Engineering Laboratory for Tree Breeding, Beijing Forestry University, Beijing 100083, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(14), 3452;
Received: 31 May 2019 / Revised: 28 June 2019 / Accepted: 11 July 2019 / Published: 13 July 2019
(This article belongs to the Special Issue Woody Formation and Lignin Biosynthesis in Plants)
PDF [2841 KB, uploaded 13 July 2019]


Histone acetylation and deacetylation play essential roles in eukaryotic gene regulation. HD2 (HD-tuins) proteins were previously identified as plant-specific histone deacetylases. In this study, we investigated the function of the HDT1 gene in the formation of stem vascular tissue in Arabidopsis thaliana. The height and thickness of the inflorescence stems in the hdt1 mutant was lower than that of wild-type plants. Paraffin sections showed that the cell number increased compared to the wild type, while transmission electron microscopy showed that the size of individual tracheary elements and fiber cells significantly decreased in the hdt1 mutant. In addition, the cell wall thickness of tracheary elements and fiber cells increased. We also found that the lignin content in the stem of the hdt1 mutants increased compared to that of the wild type. Transcriptomic data revealed that the expression levels of many biosynthetic genes related to secondary wall components, including cellulose, lignin biosynthesis, and hormone-related genes, were altered, which may lead to the altered phenotype in vascular tissue of the hdt1 mutant. These results suggested that HDT1 is involved in development of the vascular tissue of the stem by affecting cell proliferation and differentiation. View Full-Text
Keywords: HDT1; vascular tissue; stem; secondary cell wall HDT1; vascular tissue; stem; secondary cell wall

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Zhang, Y.; Yin, B.; Zhang, J.; Cheng, Z.; Liu, Y.; Wang, B.; Guo, X.; Liu, X.; Liu, D.; Li, H.; Lu, H. Histone Deacetylase HDT1 is Involved in Stem Vascular Development in Arabidopsis. Int. J. Mol. Sci. 2019, 20, 3452.

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