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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases
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Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases

1
Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy
2
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
3
Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3061; https://doi.org/10.3390/ijms20123061
Received: 31 May 2019 / Revised: 18 June 2019 / Accepted: 19 June 2019 / Published: 22 June 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
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PDF [290 KB, uploaded 22 June 2019]
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Abstract

Neuroinflammation is one of the main contributors to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Microglial and astrocyte activation is a brain defense mechanism to counteract harmful pathogens and damaged tissues, while their prolonged activation induces neuroinflammation that can trigger or exacerbate neurodegeneration. Unfortunately, to date there are no pharmacological therapies able to slow down or stop the progression of neurodegeneration. For this reason, research is turning to the identification of natural compounds with protective action against these diseases. Considering the important role of neuroinflammation in the onset and development of neurodegenerative pathologies, natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Marine organisms represent a huge source of natural compounds, and among them, algae are appreciated sources of important bioactive components such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, sterols, carotenoids, tocopherols, terpenes, phycobilins, phycocolloids, and phycocyanins. Recently, numerous anti-inflammatory compounds have been isolated from marine algae with potential protective efficacy against neuroinflammation. This review highlights the key inflammatory processes involved in neurodegeneration and the potential of specific compounds from marine algae to counteract neuroinflammation in the CNS. View Full-Text
Keywords: neuroinflammation; neurodegeneration; algae; seaweeds; neurodegenerative diseases neuroinflammation; neurodegeneration; algae; seaweeds; neurodegenerative diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Barbalace, M.C.; Malaguti, M.; Giusti, L.; Lucacchini, A.; Hrelia, S.; Angeloni, C. Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 3061.

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