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Magnetoferritin: Process, Prospects, and Their Biomedical Applications

1, 1,* and 2,*
1
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China
2
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2426; https://doi.org/10.3390/ijms20102426
Received: 23 April 2019 / Revised: 5 May 2019 / Accepted: 9 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Magnetic Soft Materials)
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PDF [3563 KB, uploaded 16 May 2019]
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Abstract

Ferritin is a spherical iron storage protein composed of 24 subunits and an iron core. Using biomimetic mineralization, magnetic iron oxide can be synthesized in the cavity of ferritin to form magnetoferritin (MFt). MFt, also known as a superparamagnetic protein, is a novel magnetic nanomaterial with good biocompatibility and flexibility for biomedical applications. Recently, it has been demonstrated that MFt had tumor targetability and a peroxidase-like catalytic activity. Thus, MFt, with its many unique properties, provides a powerful platform for tumor diagnosis and therapy. In this review, we discuss the biomimetic synthesis and biomedical applications of MFt. View Full-Text
Keywords: ferritin; magnetoferritin; magnetic protein; tumor targeting; biomedical applications ferritin; magnetoferritin; magnetic protein; tumor targeting; biomedical applications
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xue, L.; Deng, D.; Sun, J. Magnetoferritin: Process, Prospects, and Their Biomedical Applications. Int. J. Mol. Sci. 2019, 20, 2426.

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