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A Role for Lipid Mediators in Acute Myeloid Leukemia

1
Department of Medicine B, Ruppin General Hospital, Brandenburg Medical School, 16816 Neuruppin, Germany
2
Department of Internal Medicine III, University of Munich, 81377 Munich, Germany
3
Medical Department, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(10), 2425; https://doi.org/10.3390/ijms20102425
Received: 12 March 2019 / Revised: 5 May 2019 / Accepted: 6 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics 2018)
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Abstract

In spite of therapeutic improvements in the treatment of different hematologic malignancies, the prognosis of acute myeloid leukemia (AML) treated solely with conventional induction and consolidation chemotherapy remains poor, especially in association with high risk chromosomal or molecular aberrations. Recent discoveries describe the complex interaction of immune effector cells, as well as the role of the bone marrow microenvironment in the development, maintenance and progression of AML. Lipids, and in particular omega-3 as well as omega-6 polyunsaturated fatty acids (PUFAs) have been shown to play a vital role as signaling molecules of immune processes in numerous benign and malignant conditions. While the majority of research in cancer has been focused on the role of lipid mediators in solid tumors, some data are showing their involvement also in hematologic malignancies. There is a considerable amount of evidence that AML cells are targetable by innate and adaptive immune mechanisms, paving the way for immune therapy approaches in AML. In this article we review the current data showing the lipid mediator and lipidome patterns in AML and their potential links to immune mechanisms. View Full-Text
Keywords: AML; immune therapy; PGE2; omega-3; omega-6; lipidomics AML; immune therapy; PGE2; omega-3; omega-6; lipidomics
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Loew, A.; Köhnke, T.; Rehbeil, E.; Pietzner, A.; Weylandt, K.-H. A Role for Lipid Mediators in Acute Myeloid Leukemia. Int. J. Mol. Sci. 2019, 20, 2425.

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