The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
Institute of Biochemistry and Molecular Medicine, and Swiss National Center of Competence in Research (NCCR) TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland
*
Author to whom correspondence should be addressed.
†
Current address: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Int. J. Mol. Sci. 2019, 20(10), 2428; https://doi.org/10.3390/ijms20102428
Received: 20 March 2019 / Revised: 10 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Amino Acids Transport and Metabolism 2.0)
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.
View Full-Text
Keywords:
l-type amino acid transporter LAT1; cancer; preclinical studies; targeted therapy; inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Häfliger, P.; Charles, R.-P. The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer. Int. J. Mol. Sci. 2019, 20, 2428. https://doi.org/10.3390/ijms20102428
AMA Style
Häfliger P, Charles R-P. The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer. International Journal of Molecular Sciences. 2019; 20(10):2428. https://doi.org/10.3390/ijms20102428
Chicago/Turabian StyleHäfliger, Pascal; Charles, Roch-Philippe. 2019. "The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer" Int. J. Mol. Sci. 20, no. 10: 2428. https://doi.org/10.3390/ijms20102428
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
